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- NCIT_C118504 IAO_0000115 "A sublingual spray containing artemether, a semisynthetic derivative of artemisinin, an endoperoxide extracted from the Chinese herb qinghaosu (Artemisia annua or annual wormwood), with antiparasitic and potential antineoplastic activity. Upon sublingual application of the spray, artemether exerts its antineoplastic activity through as of yet not fully elucidated mechanism(s) of action. This agent binds to heme molecules inside cells, thereby inducing reactive oxygen species (ROS)-mediated damage which selectively kills cancer cells. In addition, artemether appears to target and modulate the expression of various proteins involved in cancer cell proliferation, angiogenesis, invasion and metastasis. Also, this agent depletes T regulatory cells, and modulates the production of inflammatory cytokines, such as interleukin-4 and interferon-gamma. Altogether, this inhibits tumor cell proliferation. The sublingual spray allows faster absorption of a higher percentage of the artemether dose, when compared to the oral form, as it avoids first pass metabolism; this results in an increased efficacy." @default.
- NCIT_C118504 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118504 NCIT_NHC0 "C118504" @default.
- NCIT_C118504 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118504 NCIT_P108 "Artemether Sublingual Spray" @default.
- NCIT_C118504 NCIT_P207 "C3900015" @default.
- NCIT_C118504 NCIT_P322 "GDC" @default.
- NCIT_C118504 NCIT_P329 "765719" @default.
- NCIT_C118504 NCIT_P330 "765719" @default.
- NCIT_C118504 NCIT_P375 "Artemether Sublingual Spray" @default.
- NCIT_C118504 NCIT_P399 "765719" @default.
- NCIT_C118504 normalizedInformationContent "100" @default.
- NCIT_C118504 referenceCount "1" @default.
- NCIT_C118504 hasExactSynonym "Artemether Sublingual Spray" @default.
- NCIT_C118504 hasExactSynonym "LON002" @default.
- NCIT_C118504 hasExactSynonym "Sublingual Artemether Spray" @default.
- NCIT_C118504 inSubset NCIT_C128784 @default.
- NCIT_C118504 inSubset NCIT_C157711 @default.
- NCIT_C118504 inSubset NCIT_C157712 @default.
- NCIT_C118504 inSubset NCIT_C176424 @default.
- NCIT_C118504 inSubset NCIT_C177537 @default.
- NCIT_C118504 type Class @default.
- NCIT_C118504 isDefinedBy ncit.owl @default.
- NCIT_C118504 label "Artemether Sublingual Spray" @default.
- NCIT_C118504 subClassOf NCIT_C118504 @default.
- NCIT_C118504 subClassOf NCIT_C129986 @default.
- NCIT_C118504 subClassOf NCIT_C1907 @default.
- NCIT_C118504 subClassOf NCIT_C1908 @default.
- NCIT_C118504 subClassOf NCIT_C1909 @default.
- NCIT_C118504 subClassOf NCIT_C1931 @default.
- NCIT_C118504 subClassOf NCIT_C274 @default.
- NCIT_C118504 subClassOf NCIT_C66892 @default.