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- NCIT_C118571 IAO_0000115 "An antibody-drug conjugate (ADC) composed of telisotuzumab, a monoclonal antibody against the tumor-associated antigen (TAA) and proto-oncogene, c-Met receptor tyrosine kinase (c-Met; MET; hepatocyte growth factor receptor; HGFR) conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline (vc) peptide linker (vc-MMAE; vedotin), with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of telisotuzumab vedotin targets and binds to c-Met expressed on tumor cells. Upon binding, internalization and enzymatic cleavage, the cytotoxic agent MMAE is released into the cytosol. MMAE binds to tubulin and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. This kills the c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis." @default.
- NCIT_C118571 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118571 NCIT_A7 NCIT_C18186 @default.
- NCIT_C118571 NCIT_NHC0 "C118571" @default.
- NCIT_C118571 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C118571 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118571 NCIT_P107 "Telisotuzumab Vedotin" @default.
- NCIT_C118571 NCIT_P108 "Telisotuzumab Vedotin" @default.
- NCIT_C118571 NCIT_P208 "CL474084" @default.
- NCIT_C118571 NCIT_P210 "1714088-51-3" @default.
- NCIT_C118571 NCIT_P319 "976X9VXC3Z" @default.
- NCIT_C118571 NCIT_P322 "CTRP" @default.
- NCIT_C118571 NCIT_P322 "FDA" @default.
- NCIT_C118571 NCIT_P322 "GDC" @default.
- NCIT_C118571 NCIT_P329 "759579" @default.
- NCIT_C118571 NCIT_P330 "759579" @default.
- NCIT_C118571 NCIT_P375 "Telisotuzumab Vedotin" @default.
- NCIT_C118571 NCIT_P399 "759579" @default.
- NCIT_C118571 normalizedInformationContent "100" @default.
- NCIT_C118571 referenceCount "1" @default.
- NCIT_C118571 hasExactSynonym "ABBV 399" @default.
- NCIT_C118571 hasExactSynonym "ABBV-399" @default.
- NCIT_C118571 hasExactSynonym "ABT 399" @default.
- NCIT_C118571 hasExactSynonym "ABT-399" @default.
- NCIT_C118571 hasExactSynonym "ABT-700-VCMMAE" @default.
- NCIT_C118571 hasExactSynonym "TELISOTUZUMAB VEDOTIN" @default.
- NCIT_C118571 hasExactSynonym "Telisotuzumab Vedotin" @default.
- NCIT_C118571 inSubset NCIT_C116977 @default.
- NCIT_C118571 inSubset NCIT_C116978 @default.
- NCIT_C118571 inSubset NCIT_C128784 @default.
- NCIT_C118571 inSubset NCIT_C157711 @default.
- NCIT_C118571 inSubset NCIT_C157712 @default.
- NCIT_C118571 inSubset NCIT_C176424 @default.
- NCIT_C118571 inSubset NCIT_C177537 @default.
- NCIT_C118571 inSubset NCIT_C63923 @default.
- NCIT_C118571 type Class @default.
- NCIT_C118571 isDefinedBy ncit.owl @default.
- NCIT_C118571 label "Telisotuzumab Vedotin" @default.
- NCIT_C118571 subClassOf NCIT_C118571 @default.
- NCIT_C118571 subClassOf NCIT_C129821 @default.
- NCIT_C118571 subClassOf NCIT_C129823 @default.
- NCIT_C118571 subClassOf NCIT_C1512 @default.
- NCIT_C118571 subClassOf NCIT_C163758 @default.
- NCIT_C118571 subClassOf NCIT_C164000 @default.
- NCIT_C118571 subClassOf NCIT_C1908 @default.
- NCIT_C118571 subClassOf NCIT_C1909 @default.
- NCIT_C118571 subClassOf NCIT_C201552 @default.
- NCIT_C118571 subClassOf NCIT_C274 @default.
- NCIT_C118571 subClassOf NCIT_C307 @default.
- NCIT_C118571 subClassOf NCIT_C308 @default.