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- NCIT_C118624 IAO_0000115 "An orally bioavailable inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. PI3K alpha inhibitor AZD8835 selectively binds to and inhibits PIK3CA and its mutated forms, in the PI3K/Akt (protein kinase B) /mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, this agent may be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K." @default.
- NCIT_C118624 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118624 NCIT_A7 NCIT_C30168 @default.
- NCIT_C118624 NCIT_NHC0 "C118624" @default.
- NCIT_C118624 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118624 NCIT_P107 "PI3Kalpha Inhibitor AZD8835" @default.
- NCIT_C118624 NCIT_P108 "PI3Kalpha Inhibitor AZD8835" @default.
- NCIT_C118624 NCIT_P207 "C3896907" @default.
- NCIT_C118624 NCIT_P210 "1620576-64-8" @default.
- NCIT_C118624 NCIT_P319 "8B97A88D35" @default.
- NCIT_C118624 NCIT_P322 "CTRP" @default.
- NCIT_C118624 NCIT_P322 "FDA" @default.
- NCIT_C118624 NCIT_P322 "GDC" @default.
- NCIT_C118624 NCIT_P329 "765451" @default.
- NCIT_C118624 NCIT_P330 "765451" @default.
- NCIT_C118624 NCIT_P375 "PI3Kalpha Inhibitor AZD8835" @default.
- NCIT_C118624 NCIT_P399 "765451" @default.
- NCIT_C118624 normalizedInformationContent "100" @default.
- NCIT_C118624 referenceCount "1" @default.
- NCIT_C118624 hasExactSynonym "AZD-8835" @default.
- NCIT_C118624 hasExactSynonym "AZD8835" @default.
- NCIT_C118624 hasExactSynonym "PI3Kalpha Inhibitor AZD8835" @default.
- NCIT_C118624 inSubset NCIT_C116977 @default.
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- NCIT_C118624 inSubset NCIT_C63923 @default.
- NCIT_C118624 type Class @default.
- NCIT_C118624 isDefinedBy ncit.owl @default.
- NCIT_C118624 label "PI3Kalpha Inhibitor AZD8835" @default.
- NCIT_C118624 subClassOf NCIT_C118624 @default.
- NCIT_C118624 subClassOf NCIT_C129824 @default.
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- NCIT_C118624 subClassOf NCIT_C274 @default.
- NCIT_C118624 subClassOf NCIT_C471 @default.