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- NCIT_C118625 IAO_0000115 "A soluble fusion protein containing the extracellular domain of the activin receptor type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic activity. Upon intravenous administration, STM 434 selectively binds to the growth factor activin A, thereby preventing its binding to and the activation of endogenous ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays a key role in promoting cancer cell proliferation, migration, and survival." @default.
- NCIT_C118625 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118625 NCIT_A7 NCIT_C28472 @default.
- NCIT_C118625 NCIT_NHC0 "C118625" @default.
- NCIT_C118625 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118625 NCIT_P107 "Activin Type 2B Receptor Fc Fusion Protein STM 434" @default.
- NCIT_C118625 NCIT_P108 "Activin Type 2B Receptor Fc Fusion Protein STM 434" @default.
- NCIT_C118625 NCIT_P207 "C3896763" @default.
- NCIT_C118625 NCIT_P210 "2055761-25-4" @default.
- NCIT_C118625 NCIT_P319 "7G4D2B5AC8" @default.
- NCIT_C118625 NCIT_P322 "CTRP" @default.
- NCIT_C118625 NCIT_P322 "FDA" @default.
- NCIT_C118625 NCIT_P322 "GDC" @default.
- NCIT_C118625 NCIT_P329 "765514" @default.
- NCIT_C118625 NCIT_P330 "765514" @default.
- NCIT_C118625 NCIT_P375 "Activin Type 2B Receptor Fc Fusion Protein STM 434" @default.
- NCIT_C118625 NCIT_P399 "765514" @default.
- NCIT_C118625 normalizedInformationContent "100" @default.
- NCIT_C118625 referenceCount "1" @default.
- NCIT_C118625 hasExactSynonym "Activin Inhibitor STM 434" @default.
- NCIT_C118625 hasExactSynonym "Activin Type 2B Receptor Fc Fusion Protein STM 434" @default.
- NCIT_C118625 hasExactSynonym "STM 434" @default.
- NCIT_C118625 hasExactSynonym "STM-434" @default.
- NCIT_C118625 inSubset NCIT_C116977 @default.
- NCIT_C118625 inSubset NCIT_C116978 @default.
- NCIT_C118625 inSubset NCIT_C128784 @default.
- NCIT_C118625 inSubset NCIT_C157711 @default.
- NCIT_C118625 inSubset NCIT_C157712 @default.
- NCIT_C118625 inSubset NCIT_C176424 @default.
- NCIT_C118625 inSubset NCIT_C177537 @default.
- NCIT_C118625 inSubset NCIT_C63923 @default.
- NCIT_C118625 type Class @default.
- NCIT_C118625 isDefinedBy ncit.owl @default.
- NCIT_C118625 label "Activin Type 2B Receptor Fc Fusion Protein STM 434" @default.
- NCIT_C118625 subClassOf NCIT_C118625 @default.
- NCIT_C118625 subClassOf NCIT_C1908 @default.
- NCIT_C118625 subClassOf NCIT_C1909 @default.
- NCIT_C118625 subClassOf NCIT_C2189 @default.
- NCIT_C118625 subClassOf NCIT_C274 @default.