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- NCIT_C118626 IAO_0000115 "An anti-prostate specific membrane antigen (PSMA)/anti-CD3 bispecific humanized monoclonal antibody, with potential immunostimulatory and antineoplastic activities. Anti-PSMA/CD3 monoclonal antibody MOR209/ES414 possesses two antigen-recognition sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for PSMA, a tumor-associated antigen (TAA) overexpressed on the surface of prostate tumor cells. Upon intravenous administration of MOR209/ES414, this bispecific antibody simultaneously binds to both CD3-expressing T-cells and PSMA-expressing cancer cells, thereby crosslinking PSMA-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in CTL-mediated cancer cell lysis of prostate cancer cells expressing PSMA." @default.
- NCIT_C118626 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118626 NCIT_A7 NCIT_C17796 @default.
- NCIT_C118626 NCIT_NHC0 "C118626" @default.
- NCIT_C118626 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C118626 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118626 NCIT_P107 "Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414" @default.
- NCIT_C118626 NCIT_P108 "Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414" @default.
- NCIT_C118626 NCIT_P207 "C3896808" @default.
- NCIT_C118626 NCIT_P322 "CTRP" @default.
- NCIT_C118626 NCIT_P322 "GDC" @default.
- NCIT_C118626 NCIT_P329 "765517" @default.
- NCIT_C118626 NCIT_P330 "765517" @default.
- NCIT_C118626 NCIT_P375 "Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414" @default.
- NCIT_C118626 NCIT_P399 "765517" @default.
- NCIT_C118626 NCIT_R124 NCIT_C17710 @default.
- NCIT_C118626 NCIT_R124 NCIT_C17828 @default.
- NCIT_C118626 NCIT_R124 NCIT_C18219 @default.
- NCIT_C118626 NCIT_R124 NCIT_C19986 @default.
- NCIT_C118626 NCIT_R124 NCIT_C40474 @default.
- NCIT_C118626 normalizedInformationContent "100" @default.
- NCIT_C118626 referenceCount "1" @default.
- NCIT_C118626 hasExactSynonym "Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414" @default.
- NCIT_C118626 hasExactSynonym "MOR209/ES414" @default.
- NCIT_C118626 inSubset NCIT_C116977 @default.
- NCIT_C118626 inSubset NCIT_C116978 @default.
- NCIT_C118626 inSubset NCIT_C128784 @default.
- NCIT_C118626 inSubset NCIT_C157711 @default.
- NCIT_C118626 inSubset NCIT_C157712 @default.
- NCIT_C118626 inSubset NCIT_C176424 @default.
- NCIT_C118626 inSubset NCIT_C177537 @default.
- NCIT_C118626 type Class @default.
- NCIT_C118626 isDefinedBy ncit.owl @default.
- NCIT_C118626 label "Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414" @default.
- NCIT_C118626 subClassOf NCIT_C112883 @default.
- NCIT_C118626 subClassOf NCIT_C118626 @default.
- NCIT_C118626 subClassOf NCIT_C129821 @default.
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- NCIT_C118626 subClassOf NCIT_C1454 @default.
- NCIT_C118626 subClassOf NCIT_C163758 @default.
- NCIT_C118626 subClassOf NCIT_C176017 @default.
- NCIT_C118626 subClassOf NCIT_C1908 @default.
- NCIT_C118626 subClassOf NCIT_C1909 @default.
- NCIT_C118626 subClassOf NCIT_C201282 @default.
- NCIT_C118626 subClassOf NCIT_C201543 @default.
- NCIT_C118626 subClassOf NCIT_C20401 @default.
- NCIT_C118626 subClassOf NCIT_C274 @default.
- NCIT_C118626 subClassOf NCIT_C28227 @default.
- NCIT_C118626 subClassOf NCIT_C307 @default.
- NCIT_C118626 subClassOf NCIT_C308 @default.