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- NCIT_C118629 IAO_0000115 "An orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration, INCB052793 specifically binds to and inhibits the phosphorylation of JAK1, which interferes with JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types." @default.
- NCIT_C118629 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118629 NCIT_A7 NCIT_C28493 @default.
- NCIT_C118629 NCIT_NHC0 "C118629" @default.
- NCIT_C118629 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118629 NCIT_P107 "JAK1 Inhibitor INCB052793" @default.
- NCIT_C118629 NCIT_P108 "JAK1 Inhibitor INCB052793" @default.
- NCIT_C118629 NCIT_P207 "C3896740" @default.
- NCIT_C118629 NCIT_P322 "CTRP" @default.
- NCIT_C118629 NCIT_P322 "GDC" @default.
- NCIT_C118629 NCIT_P329 "765639" @default.
- NCIT_C118629 NCIT_P330 "765639" @default.
- NCIT_C118629 NCIT_P375 "JAK1 Inhibitor INCB052793" @default.
- NCIT_C118629 NCIT_P399 "765639" @default.
- NCIT_C118629 normalizedInformationContent "100" @default.
- NCIT_C118629 referenceCount "1" @default.
- NCIT_C118629 hasExactSynonym "INCB052793" @default.
- NCIT_C118629 hasExactSynonym "JAK1 Inhibitor INCB052793" @default.
- NCIT_C118629 inSubset NCIT_C116977 @default.
- NCIT_C118629 inSubset NCIT_C116978 @default.
- NCIT_C118629 inSubset NCIT_C128784 @default.
- NCIT_C118629 inSubset NCIT_C157711 @default.
- NCIT_C118629 inSubset NCIT_C157712 @default.
- NCIT_C118629 inSubset NCIT_C176424 @default.
- NCIT_C118629 inSubset NCIT_C177537 @default.
- NCIT_C118629 type Class @default.
- NCIT_C118629 isDefinedBy ncit.owl @default.
- NCIT_C118629 label "JAK1 Inhibitor INCB052793" @default.
- NCIT_C118629 subClassOf NCIT_C118629 @default.
- NCIT_C118629 subClassOf NCIT_C129650 @default.
- NCIT_C118629 subClassOf NCIT_C129824 @default.
- NCIT_C118629 subClassOf NCIT_C129825 @default.
- NCIT_C118629 subClassOf NCIT_C1404 @default.
- NCIT_C118629 subClassOf NCIT_C172200 @default.
- NCIT_C118629 subClassOf NCIT_C1908 @default.
- NCIT_C118629 subClassOf NCIT_C1909 @default.
- NCIT_C118629 subClassOf NCIT_C1967 @default.
- NCIT_C118629 subClassOf NCIT_C2189 @default.
- NCIT_C118629 subClassOf NCIT_C274 @default.
- NCIT_C118629 subClassOf NCIT_C471 @default.