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- NCIT_C118674 IAO_0000115 "An antibody-drug conjugate (ADC) composed of the recombinant humanized anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab linked, via a cleavable linker, to the duocarmycin prodrug, seco-duocarmycin-hydroxybenzamide-azaindole (seco-DUBA), with potential antineoplastic activity. Upon administration of trastuzumab duocarmazine, the trastuzumab moiety binds to HER2 on the tumor cell surface, which triggers the endocytosis of this agent. The linker is then cleaved inside the tumor cell by proteases at the dipeptide valine-citrulline (vc), and releases the active moiety, duocarmycin. Duocarmycin binds to the minor groove of DNA, alkylates adenine at the N3 position, and induces cell death. In addition, trastuzumab induces antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress HER2. HER2 is overexpressed by many carcinomas and is associated with a poor prognosis." @default.
- NCIT_C118674 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118674 NCIT_A7 NCIT_C17319 @default.
- NCIT_C118674 NCIT_NHC0 "C118674" @default.
- NCIT_C118674 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118674 NCIT_P107 "Trastuzumab Duocarmazine" @default.
- NCIT_C118674 NCIT_P108 "Trastuzumab Duocarmazine" @default.
- NCIT_C118674 NCIT_P207 "C3896762" @default.
- NCIT_C118674 NCIT_P210 "1642152-40-6" @default.
- NCIT_C118674 NCIT_P319 "XCR2BZ80N7" @default.
- NCIT_C118674 NCIT_P322 "CTRP" @default.
- NCIT_C118674 NCIT_P322 "FDA" @default.
- NCIT_C118674 NCIT_P322 "GDC" @default.
- NCIT_C118674 NCIT_P329 "766012" @default.
- NCIT_C118674 NCIT_P330 "766012" @default.
- NCIT_C118674 NCIT_P375 "Trastuzumab Duocarmazine" @default.
- NCIT_C118674 NCIT_P399 "766012" @default.
- NCIT_C118674 normalizedInformationContent "100" @default.
- NCIT_C118674 referenceCount "1" @default.
- NCIT_C118674 hasExactSynonym "ADC SYD985" @default.
- NCIT_C118674 hasExactSynonym "Antibody-drug Conjugate SYD985" @default.
- NCIT_C118674 hasExactSynonym "SYD985" @default.
- NCIT_C118674 hasExactSynonym "TRASTUZUMAB DUOCARMAZINE" @default.
- NCIT_C118674 hasExactSynonym "Trastuzumab Duocarmazine" @default.
- NCIT_C118674 hasExactSynonym "Trastuzumab VC-seco-DUBA" @default.
- NCIT_C118674 hasExactSynonym "Trastuzumab-drug Conjugate SYD985" @default.
- NCIT_C118674 hasExactSynonym "vic-Trastuzumab Duocarmazine" @default.
- NCIT_C118674 inSubset NCIT_C116977 @default.
- NCIT_C118674 inSubset NCIT_C116978 @default.
- NCIT_C118674 inSubset NCIT_C128784 @default.
- NCIT_C118674 inSubset NCIT_C157711 @default.
- NCIT_C118674 inSubset NCIT_C157712 @default.
- NCIT_C118674 inSubset NCIT_C176424 @default.
- NCIT_C118674 inSubset NCIT_C177537 @default.
- NCIT_C118674 inSubset NCIT_C63923 @default.
- NCIT_C118674 type Class @default.
- NCIT_C118674 isDefinedBy ncit.owl @default.
- NCIT_C118674 label "Trastuzumab Duocarmazine" @default.
- NCIT_C118674 subClassOf NCIT_C118674 @default.
- NCIT_C118674 subClassOf NCIT_C129821 @default.
- NCIT_C118674 subClassOf NCIT_C129823 @default.
- NCIT_C118674 subClassOf NCIT_C1512 @default.
- NCIT_C118674 subClassOf NCIT_C155712 @default.
- NCIT_C118674 subClassOf NCIT_C163758 @default.
- NCIT_C118674 subClassOf NCIT_C163760 @default.
- NCIT_C118674 subClassOf NCIT_C1908 @default.
- NCIT_C118674 subClassOf NCIT_C1909 @default.
- NCIT_C118674 subClassOf NCIT_C274 @default.
- NCIT_C118674 subClassOf NCIT_C307 @default.
- NCIT_C118674 subClassOf NCIT_C308 @default.