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- NCIT_C118948 IAO_0000115 "An orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, taletrectinib binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression." @default.
- NCIT_C118948 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118948 NCIT_NHC0 "C118948" @default.
- NCIT_C118948 NCIT_P106 "Organic Chemical" @default.
- NCIT_C118948 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118948 NCIT_P108 "Taletrectinib" @default.
- NCIT_C118948 NCIT_P207 "C3896871" @default.
- NCIT_C118948 NCIT_P210 "1505514-27-1" @default.
- NCIT_C118948 NCIT_P319 "W4141180YD" @default.
- NCIT_C118948 NCIT_P322 "FDA" @default.
- NCIT_C118948 NCIT_P322 "GDC" @default.
- NCIT_C118948 NCIT_P329 "766123" @default.
- NCIT_C118948 NCIT_P330 "766123" @default.
- NCIT_C118948 NCIT_P375 "NTRK/ROS1 Inhibitor DS-6051b" @default.
- NCIT_C118948 NCIT_P375 "Taletrectinib" @default.
- NCIT_C118948 NCIT_P399 "766123" @default.
- NCIT_C118948 normalizedInformationContent "100" @default.
- NCIT_C118948 referenceCount "1" @default.
- NCIT_C118948 hasExactSynonym "AB 106" @default.
- NCIT_C118948 hasExactSynonym "AB-106" @default.
- NCIT_C118948 hasExactSynonym "AB106" @default.
- NCIT_C118948 hasExactSynonym "DS-6051A" @default.
- NCIT_C118948 hasExactSynonym "TALETRECTINIB" @default.
- NCIT_C118948 hasExactSynonym "Taletrectinib" @default.
- NCIT_C118948 inSubset NCIT_C128784 @default.
- NCIT_C118948 inSubset NCIT_C157711 @default.
- NCIT_C118948 inSubset NCIT_C157712 @default.
- NCIT_C118948 inSubset NCIT_C176424 @default.
- NCIT_C118948 inSubset NCIT_C177537 @default.
- NCIT_C118948 inSubset NCIT_C63923 @default.
- NCIT_C118948 type Class @default.
- NCIT_C118948 isDefinedBy ncit.owl @default.
- NCIT_C118948 label "Taletrectinib" @default.
- NCIT_C118948 subClassOf NCIT_C118948 @default.
- NCIT_C118948 subClassOf NCIT_C1404 @default.
- NCIT_C118948 subClassOf NCIT_C1908 @default.
- NCIT_C118948 subClassOf NCIT_C1909 @default.
- NCIT_C118948 subClassOf NCIT_C1967 @default.
- NCIT_C118948 subClassOf NCIT_C471 @default.