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- NCIT_C118953 IAO_0000115 "A proprietary, antibody fragment composed of a constant (Fc) region that is engineered to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2), with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell surface of various solid tumors." @default.
- NCIT_C118953 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118953 NCIT_A7 NCIT_C17319 @default.
- NCIT_C118953 NCIT_NHC0 "C118953" @default.
- NCIT_C118953 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118953 NCIT_P107 "HER2-targeting Antibody Fc Fragment FS102" @default.
- NCIT_C118953 NCIT_P108 "HER2-targeting Antibody Fc Fragment FS102" @default.
- NCIT_C118953 NCIT_P207 "C3896857" @default.
- NCIT_C118953 NCIT_P319 "Z27ZI1MZY9" @default.
- NCIT_C118953 NCIT_P322 "CTRP" @default.
- NCIT_C118953 NCIT_P322 "FDA" @default.
- NCIT_C118953 NCIT_P322 "GDC" @default.
- NCIT_C118953 NCIT_P329 "766415" @default.
- NCIT_C118953 NCIT_P330 "766415" @default.
- NCIT_C118953 NCIT_P375 "HER2-targeting Antibody Fc Fragment FS102" @default.
- NCIT_C118953 NCIT_P399 "766415" @default.
- NCIT_C118953 normalizedInformationContent "100" @default.
- NCIT_C118953 referenceCount "1" @default.
- NCIT_C118953 hasExactSynonym "Anti-HER2 FCAB FS102" @default.
- NCIT_C118953 hasExactSynonym "BMS-986186" @default.
- NCIT_C118953 hasExactSynonym "FS-102" @default.
- NCIT_C118953 hasExactSynonym "FS102" @default.
- NCIT_C118953 hasExactSynonym "Fcab FS102" @default.
- NCIT_C118953 hasExactSynonym "HER2-targeting Antibody Fc Fragment FS102" @default.
- NCIT_C118953 inSubset NCIT_C116977 @default.
- NCIT_C118953 inSubset NCIT_C116978 @default.
- NCIT_C118953 inSubset NCIT_C128784 @default.
- NCIT_C118953 inSubset NCIT_C157711 @default.
- NCIT_C118953 inSubset NCIT_C157712 @default.
- NCIT_C118953 inSubset NCIT_C176424 @default.
- NCIT_C118953 inSubset NCIT_C177537 @default.
- NCIT_C118953 inSubset NCIT_C63923 @default.
- NCIT_C118953 type Class @default.
- NCIT_C118953 isDefinedBy ncit.owl @default.
- NCIT_C118953 label "HER2-targeting Antibody Fc Fragment FS102" @default.
- NCIT_C118953 subClassOf NCIT_C118953 @default.
- NCIT_C118953 subClassOf NCIT_C129820 @default.
- NCIT_C118953 subClassOf NCIT_C129821 @default.
- NCIT_C118953 subClassOf NCIT_C1908 @default.
- NCIT_C118953 subClassOf NCIT_C1909 @default.
- NCIT_C118953 subClassOf NCIT_C274 @default.
- NCIT_C118953 subClassOf NCIT_C307 @default.
- NCIT_C118953 subClassOf NCIT_C308 @default.