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- NCIT_C118973 IAO_0000115 "A vaccine consisting of the attenuated, genetically-modified, oncolytic form of the Maraba virus, MG1, which has been engineered to express a gene encoding the cancer testis antigen melanoma antigen family A3 (MAGE-A3), with potential antineoplastic activity. Upon administration of genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine, the attenuated Maraba virus selectively and rapidly replicates in cancer cells; however, it is unable to replicate in normal, healthy cells. This induces a selective Maraba virus-mediated cytotoxicity in those cancer cells, and leads to cancer cell lysis. In addition, the expression of MAGE-A3 further stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing MAGE-A3. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types. The attenuated virus is a double mutant strain with single amino acid substitutions occurring in both G protein (Q242R) and M protein (L123W)." @default.
- NCIT_C118973 NCIT_NHC0 "C118973" @default.
- NCIT_C118973 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118973 NCIT_P106 "Virus" @default.
- NCIT_C118973 NCIT_P108 "Genetically-modified MAGE-A3-expressing MG1 Maraba Virus Vaccine" @default.
- NCIT_C118973 NCIT_P207 "C3896648" @default.
- NCIT_C118973 NCIT_P329 "766627" @default.
- NCIT_C118973 NCIT_P330 "766627" @default.
- NCIT_C118973 NCIT_P399 "766627" @default.
- NCIT_C118973 normalizedInformationContent "100" @default.
- NCIT_C118973 referenceCount "1" @default.
- NCIT_C118973 hasExactSynonym "Genetically-modified MAGE-A3-expressing MG1 Maraba Virus Vaccine" @default.
- NCIT_C118973 hasExactSynonym "MG1 Maraba/MAGE-A3" @default.
- NCIT_C118973 hasExactSynonym "MG1MA3" @default.
- NCIT_C118973 inSubset NCIT_C128784 @default.
- NCIT_C118973 inSubset NCIT_C176424 @default.
- NCIT_C118973 type Class @default.
- NCIT_C118973 isDefinedBy ncit.owl @default.
- NCIT_C118973 label "Genetically-modified MAGE-A3-expressing MG1 Maraba Virus Vaccine" @default.
- NCIT_C118973 subClassOf NCIT_C118973 @default.
- NCIT_C118973 subClassOf NCIT_C129820 @default.
- NCIT_C118973 subClassOf NCIT_C1663 @default.
- NCIT_C118973 subClassOf NCIT_C1908 @default.
- NCIT_C118973 subClassOf NCIT_C1909 @default.
- NCIT_C118973 subClassOf NCIT_C1920 @default.
- NCIT_C118973 subClassOf NCIT_C274 @default.
- NCIT_C118973 subClassOf NCIT_C307 @default.
- NCIT_C118973 subClassOf NCIT_C308 @default.
- NCIT_C118973 subClassOf NCIT_C923 @default.
- NCIT_C118973 subClassOf NCIT_C96404 @default.
- NCIT_C118973 subClassOf NCIT_C97116 @default.