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- NCIT_C119619 IAO_0000115 "A humanized monoclonal antibody targeting the alpha chain of the extracellular domain of human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic activity. Anti-c-Met monoclonal antibody SAIT301 binds to c-Met, thereby preventing both binding of its ligand, HGF, and the subsequent activation of the HGF/c-Met signaling pathway. In addition, SAIT301 induces c-MET internalization and subsequent degradation, which further inhibits c-Met-mediated signaling. This leads to a reduction in the proliferation of c-Met-expressing cancer cells. c-Met, a proto-oncogene receptor tyrosine kinase overexpressed in certain cancer cell types, is involved in various tumors." @default.
- NCIT_C119619 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119619 NCIT_NHC0 "C119619" @default.
- NCIT_C119619 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C119619 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C119619 NCIT_P108 "Anti-C-met Monoclonal Antibody SAIT301" @default.
- NCIT_C119619 NCIT_P207 "C3896772" @default.
- NCIT_C119619 NCIT_P322 "GDC" @default.
- NCIT_C119619 NCIT_P329 "766799" @default.
- NCIT_C119619 NCIT_P330 "766799" @default.
- NCIT_C119619 NCIT_P375 "Anti-C-met Monoclonal Antibody SAIT301" @default.
- NCIT_C119619 NCIT_P399 "766799" @default.
- NCIT_C119619 NCIT_R124 NCIT_C17710 @default.
- NCIT_C119619 NCIT_R124 NCIT_C17828 @default.
- NCIT_C119619 NCIT_R124 NCIT_C18219 @default.
- NCIT_C119619 NCIT_R124 NCIT_C19986 @default.
- NCIT_C119619 NCIT_R124 NCIT_C40474 @default.
- NCIT_C119619 normalizedInformationContent "100" @default.
- NCIT_C119619 referenceCount "1" @default.
- NCIT_C119619 hasExactSynonym "Anti-C-met Monoclonal Antibody SAIT301" @default.
- NCIT_C119619 hasExactSynonym "SAIT301" @default.
- NCIT_C119619 inSubset NCIT_C128784 @default.
- NCIT_C119619 inSubset NCIT_C157711 @default.
- NCIT_C119619 inSubset NCIT_C157712 @default.
- NCIT_C119619 inSubset NCIT_C176424 @default.
- NCIT_C119619 inSubset NCIT_C177537 @default.
- NCIT_C119619 type Class @default.
- NCIT_C119619 isDefinedBy ncit.owl @default.
- NCIT_C119619 label "Anti-C-met Monoclonal Antibody SAIT301" @default.
- NCIT_C119619 subClassOf NCIT_C119619 @default.
- NCIT_C119619 subClassOf NCIT_C129821 @default.
- NCIT_C119619 subClassOf NCIT_C129822 @default.
- NCIT_C119619 subClassOf NCIT_C163758 @default.
- NCIT_C119619 subClassOf NCIT_C164000 @default.
- NCIT_C119619 subClassOf NCIT_C164001 @default.
- NCIT_C119619 subClassOf NCIT_C1908 @default.
- NCIT_C119619 subClassOf NCIT_C1909 @default.
- NCIT_C119619 subClassOf NCIT_C20401 @default.
- NCIT_C119619 subClassOf NCIT_C274 @default.
- NCIT_C119619 subClassOf NCIT_C307 @default.
- NCIT_C119619 subClassOf NCIT_C308 @default.