Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C119623> ?p ?o ?g. }
Showing items 1 to 31 of
31
with 100 items per page.
- NCIT_C119623 IAO_0000115 "An orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration, sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid." @default.
- NCIT_C119623 NCIT_NHC0 "C119623" @default.
- NCIT_C119623 NCIT_P106 "Organic Chemical" @default.
- NCIT_C119623 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119623 NCIT_P108 "Sotagliflozin" @default.
- NCIT_C119623 NCIT_P207 "C3502472" @default.
- NCIT_C119623 NCIT_P210 "1018899-04-1" @default.
- NCIT_C119623 NCIT_P319 "6B4ZBS263Y" @default.
- NCIT_C119623 NCIT_P322 "FDA" @default.
- NCIT_C119623 NCIT_P329 "766941" @default.
- NCIT_C119623 NCIT_P330 "766941" @default.
- NCIT_C119623 NCIT_P399 "766941" @default.
- NCIT_C119623 normalizedInformationContent "100" @default.
- NCIT_C119623 referenceCount "1" @default.
- NCIT_C119623 hasExactSynonym "Beta-l-Xylopyranoside, methyl 5-C-(4-chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-thio-, (5S)-" @default.
- NCIT_C119623 hasExactSynonym "LP 802034" @default.
- NCIT_C119623 hasExactSynonym "LX4211" @default.
- NCIT_C119623 hasExactSynonym "SOTAGLIFLOZIN" @default.
- NCIT_C119623 hasExactSynonym "Sotagliflozin" @default.
- NCIT_C119623 inSubset NCIT_C176424 @default.
- NCIT_C119623 inSubset NCIT_C63923 @default.
- NCIT_C119623 type Class @default.
- NCIT_C119623 isDefinedBy ncit.owl @default.
- NCIT_C119623 label "Sotagliflozin" @default.
- NCIT_C119623 subClassOf NCIT_C119623 @default.
- NCIT_C119623 subClassOf NCIT_C1908 @default.
- NCIT_C119623 subClassOf NCIT_C1909 @default.
- NCIT_C119623 subClassOf NCIT_C29711 @default.
- NCIT_C119623 subClassOf NCIT_C471 @default.
- NCIT_C119623 subClassOf NCIT_C78276 @default.
- NCIT_C119623 subClassOf NCIT_C98083 @default.