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- NCIT_C119624 IAO_0000115 "An orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance. This agent shows minimal activity against wild-type EGFR (WT EGFR), and does not cause dose-limiting toxicities that are seen with the use of non-selective EGFR inhibitors, which also inhibit WT EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C119624 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119624 NCIT_NHC0 "C119624" @default.
- NCIT_C119624 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119624 NCIT_P108 "Mutant-selective EGFR Inhibitor PF-06459988" @default.
- NCIT_C119624 NCIT_P207 "C3896788" @default.
- NCIT_C119624 NCIT_P210 "1428774-45-1" @default.
- NCIT_C119624 NCIT_P319 "5IE92SK9EB" @default.
- NCIT_C119624 NCIT_P322 "FDA" @default.
- NCIT_C119624 NCIT_P322 "GDC" @default.
- NCIT_C119624 NCIT_P329 "766942" @default.
- NCIT_C119624 NCIT_P330 "766942" @default.
- NCIT_C119624 NCIT_P375 "Mutant-selective EGFR Inhibitor PF-06459988" @default.
- NCIT_C119624 NCIT_P399 "766942" @default.
- NCIT_C119624 normalizedInformationContent "100" @default.
- NCIT_C119624 referenceCount "1" @default.
- NCIT_C119624 hasExactSynonym "Mutant-selective EGFR Inhibitor PF-06459988" @default.
- NCIT_C119624 hasExactSynonym "PF-06459988" @default.
- NCIT_C119624 inSubset NCIT_C128784 @default.
- NCIT_C119624 inSubset NCIT_C157711 @default.
- NCIT_C119624 inSubset NCIT_C157712 @default.
- NCIT_C119624 inSubset NCIT_C176424 @default.
- NCIT_C119624 inSubset NCIT_C177537 @default.
- NCIT_C119624 inSubset NCIT_C63923 @default.
- NCIT_C119624 type Class @default.
- NCIT_C119624 isDefinedBy ncit.owl @default.
- NCIT_C119624 label "Mutant-selective EGFR Inhibitor PF-06459988" @default.
- NCIT_C119624 subClassOf NCIT_C119624 @default.
- NCIT_C119624 subClassOf NCIT_C129824 @default.
- NCIT_C119624 subClassOf NCIT_C129825 @default.
- NCIT_C119624 subClassOf NCIT_C1404 @default.
- NCIT_C119624 subClassOf NCIT_C1908 @default.
- NCIT_C119624 subClassOf NCIT_C1909 @default.
- NCIT_C119624 subClassOf NCIT_C1967 @default.
- NCIT_C119624 subClassOf NCIT_C2189 @default.
- NCIT_C119624 subClassOf NCIT_C274 @default.
- NCIT_C119624 subClassOf NCIT_C471 @default.