Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C119665> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- NCIT_C119665 IAO_0000115 "The fumarate salt form of gilteritinib, an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase (ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic activity. Upon administration, gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-, AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed or mutated in a variety of cancer cell types, play key roles in tumor cell growth and survival." @default.
- NCIT_C119665 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119665 NCIT_A6 NCIT_C116722 @default.
- NCIT_C119665 NCIT_A7 NCIT_C17475 @default.
- NCIT_C119665 NCIT_A7 NCIT_C26202 @default.
- NCIT_C119665 NCIT_A7 NCIT_C26332 @default.
- NCIT_C119665 NCIT_A7 NCIT_C27032 @default.
- NCIT_C119665 NCIT_NHC0 "C119665" @default.
- NCIT_C119665 NCIT_P106 "Organic Chemical" @default.
- NCIT_C119665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119665 NCIT_P107 "Gilteritinib Fumarate" @default.
- NCIT_C119665 NCIT_P108 "Gilteritinib Fumarate" @default.
- NCIT_C119665 NCIT_P207 "C3896946" @default.
- NCIT_C119665 NCIT_P210 "1254053-84-3" @default.
- NCIT_C119665 NCIT_P302 "adults with acute myeloid leukemia (AML) with a FMS-like tyrosine kinase 3 (FLT3) mutation when the disease has come back or has not improved after previous treatment(s)." @default.
- NCIT_C119665 NCIT_P302 "relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation" @default.
- NCIT_C119665 NCIT_P319 "5RZZ0Z1GJT" @default.
- NCIT_C119665 NCIT_P322 "CTRP" @default.
- NCIT_C119665 NCIT_P322 "FDA" @default.
- NCIT_C119665 NCIT_P322 "GDC" @default.
- NCIT_C119665 NCIT_P329 "792549" @default.
- NCIT_C119665 NCIT_P330 "792549" @default.
- NCIT_C119665 NCIT_P375 "Gilteritinib Fumarate" @default.
- NCIT_C119665 NCIT_P399 "792549" @default.
- NCIT_C119665 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C119665 referenceCount "2" @default.
- NCIT_C119665 hasExactSynonym "2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-, (2E)-2-Butenedioate (2:1)" @default.
- NCIT_C119665 hasExactSynonym "ASP-2215 Hemifumarate" @default.
- NCIT_C119665 hasExactSynonym "ASP2215 Hemifumarate" @default.
- NCIT_C119665 hasExactSynonym "GILTERITINIB FUMARATE" @default.
- NCIT_C119665 hasExactSynonym "Gilteritinib Fumarate" @default.
- NCIT_C119665 hasExactSynonym "Gilteritinib Hemifumarate" @default.
- NCIT_C119665 hasExactSynonym "Xospata" @default.
- NCIT_C119665 inSubset NCIT_C116977 @default.
- NCIT_C119665 inSubset NCIT_C116978 @default.
- NCIT_C119665 inSubset NCIT_C128784 @default.
- NCIT_C119665 inSubset NCIT_C157711 @default.
- NCIT_C119665 inSubset NCIT_C157712 @default.
- NCIT_C119665 inSubset NCIT_C176424 @default.
- NCIT_C119665 inSubset NCIT_C177537 @default.
- NCIT_C119665 inSubset NCIT_C63923 @default.
- NCIT_C119665 type Class @default.
- NCIT_C119665 isDefinedBy ncit.owl @default.
- NCIT_C119665 label "Gilteritinib Fumarate" @default.
- NCIT_C119665 subClassOf NCIT_C119665 @default.
- NCIT_C119665 subClassOf NCIT_C1404 @default.
- NCIT_C119665 subClassOf NCIT_C1908 @default.
- NCIT_C119665 subClassOf NCIT_C1909 @default.
- NCIT_C119665 subClassOf NCIT_C1967 @default.
- NCIT_C119665 subClassOf NCIT_C471 @default.