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- NCIT_C119700 IAO_0000115 "An antibody-drug conjugate (ADC) composed of AGS67C, a human anti-CD37 monoclonal antibody covalently linked, via reduced cysteines and a protease cleavable linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of AGS67E binds to CD37 antigens on tumor B-cells and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies." @default.
- NCIT_C119700 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119700 NCIT_A7 NCIT_C102769 @default.
- NCIT_C119700 NCIT_NHC0 "C119700" @default.
- NCIT_C119700 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119700 NCIT_P107 "Anti-CD37 MMAE Antibody-drug Conjugate AGS67E" @default.
- NCIT_C119700 NCIT_P108 "Anti-CD37 MMAE Antibody-drug Conjugate AGS67E" @default.
- NCIT_C119700 NCIT_P207 "C3896733" @default.
- NCIT_C119700 NCIT_P322 "CTRP" @default.
- NCIT_C119700 NCIT_P322 "GDC" @default.
- NCIT_C119700 NCIT_P329 "762606" @default.
- NCIT_C119700 NCIT_P330 "762606" @default.
- NCIT_C119700 NCIT_P375 "Anti-CD37 MMAE Antibody-drug Conjugate AGS67E" @default.
- NCIT_C119700 NCIT_P399 "762606" @default.
- NCIT_C119700 normalizedInformationContent "100" @default.
- NCIT_C119700 referenceCount "1" @default.
- NCIT_C119700 hasExactSynonym "AGS67E" @default.
- NCIT_C119700 hasExactSynonym "Anti-CD37 MMAE ADC AGS67E" @default.
- NCIT_C119700 hasExactSynonym "Anti-CD37 MMAE Antibody-drug Conjugate AGS67E" @default.
- NCIT_C119700 inSubset NCIT_C116977 @default.
- NCIT_C119700 inSubset NCIT_C116978 @default.
- NCIT_C119700 inSubset NCIT_C128784 @default.
- NCIT_C119700 inSubset NCIT_C157711 @default.
- NCIT_C119700 inSubset NCIT_C157712 @default.
- NCIT_C119700 inSubset NCIT_C176424 @default.
- NCIT_C119700 inSubset NCIT_C177537 @default.
- NCIT_C119700 type Class @default.
- NCIT_C119700 isDefinedBy ncit.owl @default.
- NCIT_C119700 label "Anti-CD37 MMAE Antibody-drug Conjugate AGS67E" @default.
- NCIT_C119700 subClassOf NCIT_C119700 @default.
- NCIT_C119700 subClassOf NCIT_C129821 @default.
- NCIT_C119700 subClassOf NCIT_C129823 @default.
- NCIT_C119700 subClassOf NCIT_C1512 @default.
- NCIT_C119700 subClassOf NCIT_C1908 @default.
- NCIT_C119700 subClassOf NCIT_C1909 @default.
- NCIT_C119700 subClassOf NCIT_C274 @default.
- NCIT_C119700 subClassOf NCIT_C307 @default.
- NCIT_C119700 subClassOf NCIT_C308 @default.