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- NCIT_C119701 IAO_0000115 "An orally available capsule containing antroquinonol, a farnesylated quinone derivative isolated from the mycelium of Antrodia camphorata, with potential antineoplastic activity. Upon oral administration, antroquinonol binds to and inhibits protein prenylation mediated by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase 1 (GGTase-1). This prevents both post-translational prenylation and signaling activity of a number of Ras superfamily proteins, such as Ras and Rho. This results in the inhibition of downstream signaling, such as the PI3K/mTOR signaling pathway, and induces apoptosis in susceptible tumor cells. Ras superfamily proteins are overexpressed in numerous cancer cell types, and play a key role in tumor cell proliferation and survival." @default.
- NCIT_C119701 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119701 NCIT_A7 NCIT_C17526 @default.
- NCIT_C119701 NCIT_A7 NCIT_C41056 @default.
- NCIT_C119701 NCIT_NHC0 "C119701" @default.
- NCIT_C119701 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119701 NCIT_P107 "Antroquinonol Capsule" @default.
- NCIT_C119701 NCIT_P108 "Antroquinonol Capsule" @default.
- NCIT_C119701 NCIT_P208 "CL421596" @default.
- NCIT_C119701 NCIT_P210 "1010081-09-0" @default.
- NCIT_C119701 NCIT_P319 "AX9P92T7JZ" @default.
- NCIT_C119701 NCIT_P322 "CTRP" @default.
- NCIT_C119701 NCIT_P322 "FDA" @default.
- NCIT_C119701 NCIT_P322 "GDC" @default.
- NCIT_C119701 NCIT_P329 "674922" @default.
- NCIT_C119701 NCIT_P330 "674922" @default.
- NCIT_C119701 NCIT_P375 "Antroquinonol Capsule" @default.
- NCIT_C119701 NCIT_P399 "674922" @default.
- NCIT_C119701 normalizedInformationContent "100" @default.
- NCIT_C119701 referenceCount "1" @default.
- NCIT_C119701 hasExactSynonym "ANTROQUINONOL" @default.
- NCIT_C119701 hasExactSynonym "Antroquinonol Capsule" @default.
- NCIT_C119701 hasExactSynonym "Hocena" @default.
- NCIT_C119701 inSubset NCIT_C116977 @default.
- NCIT_C119701 inSubset NCIT_C116978 @default.
- NCIT_C119701 inSubset NCIT_C128784 @default.
- NCIT_C119701 inSubset NCIT_C157711 @default.
- NCIT_C119701 inSubset NCIT_C157712 @default.
- NCIT_C119701 inSubset NCIT_C173381 @default.
- NCIT_C119701 inSubset NCIT_C173383 @default.
- NCIT_C119701 inSubset NCIT_C176424 @default.
- NCIT_C119701 inSubset NCIT_C177537 @default.
- NCIT_C119701 inSubset NCIT_C63923 @default.
- NCIT_C119701 type Class @default.
- NCIT_C119701 isDefinedBy ncit.owl @default.
- NCIT_C119701 label "Antroquinonol Capsule" @default.
- NCIT_C119701 subClassOf NCIT_C119701 @default.
- NCIT_C119701 subClassOf NCIT_C1908 @default.
- NCIT_C119701 subClassOf NCIT_C1909 @default.
- NCIT_C119701 subClassOf NCIT_C471 @default.