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- NCIT_C119702 IAO_0000115 "A radioconjugate composed of the platinum compound carboplatin conjugated to the isotope carbon C 14 (14C-carboplatin), which can potentially be used to predict chemoresistance to carboplatin using accelerator mass spectrometry (AMS). Upon administration of a microdose of 14C-carboplatin, the carboplatin moiety covalently binds to DNA and forms carboplatin-DNA monoadducts. Using AMS, the 14C-carboplatin-DNA monoadducts can be detected and measured. The levels of microdose-induced carboplatin-DNA monoadducts can be used to assess the degree of chemoresistance to carboplatin and can predict cancer response to carboplatin-based chemotherapy. The carboplatin microdose is defined as 1/100 of the pharmacologically effective concentration of carboplatin. Low levels of carboplatin monoadduct formation and increased DNA repair, measured by a decrease in the detection of carboplatin-DNA monoadducts over a given time period, are correlated with increased resistance to platinum-based chemotherapeutics." @default.
- NCIT_C119702 NCIT_NHC0 "C119702" @default.
- NCIT_C119702 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119702 NCIT_P107 "Carbon C14-labeled Carboplatin" @default.
- NCIT_C119702 NCIT_P108 "Carbon C14-labeled Carboplatin" @default.
- NCIT_C119702 NCIT_P207 "C3899706" @default.
- NCIT_C119702 NCIT_P322 "CTRP" @default.
- NCIT_C119702 NCIT_P399 "810807" @default.
- NCIT_C119702 normalizedInformationContent "100" @default.
- NCIT_C119702 referenceCount "1" @default.
- NCIT_C119702 hasExactSynonym "14C Carboplatin" @default.
- NCIT_C119702 hasExactSynonym "Carbon C14-labeled Carboplatin" @default.
- NCIT_C119702 hasExactSynonym "Carbon-14-labeled Carboplatin" @default.
- NCIT_C119702 inSubset NCIT_C116977 @default.
- NCIT_C119702 inSubset NCIT_C116978 @default.
- NCIT_C119702 inSubset NCIT_C176424 @default.
- NCIT_C119702 type Class @default.
- NCIT_C119702 isDefinedBy ncit.owl @default.
- NCIT_C119702 label "Carbon C14-labeled Carboplatin" @default.
- NCIT_C119702 subClassOf NCIT_C119702 @default.
- NCIT_C119702 subClassOf NCIT_C1446 @default.
- NCIT_C119702 subClassOf NCIT_C1908 @default.
- NCIT_C119702 subClassOf NCIT_C1909 @default.
- NCIT_C119702 subClassOf NCIT_C2124 @default.