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- NCIT_C119738 IAO_0000115 "A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the beta-emitting radionuclide yttrium 90 (Y-90), with radioimmunotherapeutic activity. After pre-treating and targeting tumor cells with a bi-specific monoclonal antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of the administered yttrium Y 90-DOTA-di-HSG peptide IMP-288 binds to the anti-HSG sequence on the BiMoAB. In turn, Y-90 delivers a cytotoxic dose of beta radiation to tumor cells expressing the specific TAA." @default.
- NCIT_C119738 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119738 NCIT_NHC0 "C119738" @default.
- NCIT_C119738 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119738 NCIT_P108 "Yttrium Y 90-DOTA-di-HSG Peptide IMP-288" @default.
- NCIT_C119738 NCIT_P207 "C3896702" @default.
- NCIT_C119738 NCIT_P322 "GDC" @default.
- NCIT_C119738 NCIT_P329 "766993" @default.
- NCIT_C119738 NCIT_P330 "766993" @default.
- NCIT_C119738 NCIT_P375 "Yttrium Y 90-DOTA-di-HSG Peptide IMP-288" @default.
- NCIT_C119738 NCIT_P399 "766993" @default.
- NCIT_C119738 normalizedInformationContent "100" @default.
- NCIT_C119738 referenceCount "1" @default.
- NCIT_C119738 hasExactSynonym "90-Y-IMP-288" @default.
- NCIT_C119738 hasExactSynonym "90Y-IMP288" @default.
- NCIT_C119738 hasExactSynonym "Yttrium Y 90-DOTA-di-HSG Peptide IMP-288" @default.
- NCIT_C119738 inSubset NCIT_C128784 @default.
- NCIT_C119738 inSubset NCIT_C157711 @default.
- NCIT_C119738 inSubset NCIT_C157712 @default.
- NCIT_C119738 inSubset NCIT_C176424 @default.
- NCIT_C119738 inSubset NCIT_C177537 @default.
- NCIT_C119738 type Class @default.
- NCIT_C119738 isDefinedBy ncit.owl @default.
- NCIT_C119738 label "Yttrium Y 90-DOTA-di-HSG Peptide IMP-288" @default.
- NCIT_C119738 subClassOf NCIT_C119738 @default.
- NCIT_C119738 subClassOf NCIT_C129819 @default.
- NCIT_C119738 subClassOf NCIT_C1446 @default.
- NCIT_C119738 subClassOf NCIT_C1908 @default.
- NCIT_C119738 subClassOf NCIT_C1909 @default.
- NCIT_C119738 subClassOf NCIT_C2124 @default.
- NCIT_C119738 subClassOf NCIT_C274 @default.