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- NCIT_C119740 IAO_0000115 "A human immunoglobulin G2 (IgG2) monoclonal antibody agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, selicrelumab targets and binds to CD40 expressed on a variety of immune cell types. This induces CD40-dependent signaling pathways and triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced anti-tumor immune response. CD40, a cell surface receptor and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells and certain cancer cells; it plays a key role in the activation of the immune system." @default.
- NCIT_C119740 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119740 NCIT_A7 NCIT_C17281 @default.
- NCIT_C119740 NCIT_NHC0 "C119740" @default.
- NCIT_C119740 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C119740 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C119740 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119740 NCIT_P107 "Selicrelumab" @default.
- NCIT_C119740 NCIT_P108 "Selicrelumab" @default.
- NCIT_C119740 NCIT_P207 "C3896775" @default.
- NCIT_C119740 NCIT_P210 "1622140-49-1" @default.
- NCIT_C119740 NCIT_P319 "0O39RGI33V" @default.
- NCIT_C119740 NCIT_P322 "CTRP" @default.
- NCIT_C119740 NCIT_P322 "FDA" @default.
- NCIT_C119740 NCIT_P322 "GDC" @default.
- NCIT_C119740 NCIT_P329 "767014" @default.
- NCIT_C119740 NCIT_P330 "767014" @default.
- NCIT_C119740 NCIT_P366 "Anti-CD40_Monoclonal_Antibody_CP-870_893" @default.
- NCIT_C119740 NCIT_P375 "CD40 Agonist Monoclonal Antibody CP-870,893" @default.
- NCIT_C119740 NCIT_P375 "Selicrelumab" @default.
- NCIT_C119740 NCIT_P399 "588974" @default.
- NCIT_C119740 NCIT_P399 "767014" @default.
- NCIT_C119740 NCIT_R124 NCIT_C17710 @default.
- NCIT_C119740 NCIT_R124 NCIT_C17828 @default.
- NCIT_C119740 NCIT_R124 NCIT_C18219 @default.
- NCIT_C119740 NCIT_R124 NCIT_C19986 @default.
- NCIT_C119740 NCIT_R124 NCIT_C40474 @default.
- NCIT_C119740 normalizedInformationContent "100" @default.
- NCIT_C119740 referenceCount "1" @default.
- NCIT_C119740 hasExactSynonym "CD40 Agonist Monoclonal Antibody CP-870,893" @default.
- NCIT_C119740 hasExactSynonym "CP-870,893" @default.
- NCIT_C119740 hasExactSynonym "RO7009789" @default.
- NCIT_C119740 hasExactSynonym "SELICRELUMAB" @default.
- NCIT_C119740 hasExactSynonym "Selicrelumab" @default.
- NCIT_C119740 inSubset NCIT_C116977 @default.
- NCIT_C119740 inSubset NCIT_C116978 @default.
- NCIT_C119740 inSubset NCIT_C128784 @default.
- NCIT_C119740 inSubset NCIT_C157711 @default.
- NCIT_C119740 inSubset NCIT_C157712 @default.
- NCIT_C119740 inSubset NCIT_C176424 @default.
- NCIT_C119740 inSubset NCIT_C177537 @default.
- NCIT_C119740 inSubset NCIT_C63923 @default.
- NCIT_C119740 type Class @default.
- NCIT_C119740 isDefinedBy ncit.owl @default.
- NCIT_C119740 label "Selicrelumab" @default.
- NCIT_C119740 subClassOf B2e6d3d0898b1004184178e8ea3fad5a9 @default.
- NCIT_C119740 subClassOf Bde6a1a44773098c4612e18f0f4327ffc @default.
- NCIT_C119740 subClassOf NCIT_C119740 @default.
- NCIT_C119740 subClassOf NCIT_C129820 @default.
- NCIT_C119740 subClassOf NCIT_C133877 @default.
- NCIT_C119740 subClassOf NCIT_C1908 @default.
- NCIT_C119740 subClassOf NCIT_C1909 @default.
- NCIT_C119740 subClassOf NCIT_C191767 @default.
- NCIT_C119740 subClassOf NCIT_C20401 @default.
- NCIT_C119740 subClassOf NCIT_C274 @default.
- NCIT_C119740 subClassOf NCIT_C307 @default.
- NCIT_C119740 subClassOf NCIT_C308 @default.