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- NCIT_C119743 IAO_0000115 "A synthetic, glycomimetic molecule and E-selectin (CD62E) antagonist, with potential anti-thrombotic, antineoplastic and chemopotentiating activities. Upon administration, uproleselan binds to E-selectin expressed on endothelial cells and prevents their interaction with selectin-E ligand-expressing cancer cells. This may prevent tumor cell activation, migration and metastasis. GMI-1271 also interferes with the binding of selectin E-expressing vascular endothelial cells to selectin-E ligand-expressing monocytes and neutrophils, thereby disrupting their activation. Consequently, this inhibits both the activation of the coagulation cascade and thrombus formation. This agent also prevents both leukocyte activation and inflammation. E-selectin is a cell adhesion molecule involved in cell rolling, signaling and chemotaxis; it also plays a crucial role in inflammatory processes and cancer." @default.
- NCIT_C119743 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119743 NCIT_A7 NCIT_C17491 @default.
- NCIT_C119743 NCIT_NHC0 "C119743" @default.
- NCIT_C119743 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119743 NCIT_P107 "Uproleselan" @default.
- NCIT_C119743 NCIT_P108 "Uproleselan" @default.
- NCIT_C119743 NCIT_P207 "C3896849" @default.
- NCIT_C119743 NCIT_P210 "1983970-12-2" @default.
- NCIT_C119743 NCIT_P319 "PE952ANF83" @default.
- NCIT_C119743 NCIT_P322 "CTRP" @default.
- NCIT_C119743 NCIT_P322 "FDA" @default.
- NCIT_C119743 NCIT_P322 "GDC" @default.
- NCIT_C119743 NCIT_P329 "767121" @default.
- NCIT_C119743 NCIT_P330 "767121" @default.
- NCIT_C119743 NCIT_P375 "Uproleselan" @default.
- NCIT_C119743 NCIT_P399 "767121" @default.
- NCIT_C119743 normalizedInformationContent "100" @default.
- NCIT_C119743 referenceCount "1" @default.
- NCIT_C119743 hasExactSynonym "GMI-1271" @default.
- NCIT_C119743 hasExactSynonym "UPROLESELAN" @default.
- NCIT_C119743 hasExactSynonym "Uproleselan" @default.
- NCIT_C119743 inSubset NCIT_C116977 @default.
- NCIT_C119743 inSubset NCIT_C116978 @default.
- NCIT_C119743 inSubset NCIT_C128784 @default.
- NCIT_C119743 inSubset NCIT_C157711 @default.
- NCIT_C119743 inSubset NCIT_C157712 @default.
- NCIT_C119743 inSubset NCIT_C173381 @default.
- NCIT_C119743 inSubset NCIT_C173383 @default.
- NCIT_C119743 inSubset NCIT_C176424 @default.
- NCIT_C119743 inSubset NCIT_C177537 @default.
- NCIT_C119743 inSubset NCIT_C63923 @default.
- NCIT_C119743 type Class @default.
- NCIT_C119743 isDefinedBy ncit.owl @default.
- NCIT_C119743 label "Uproleselan" @default.
- NCIT_C119743 subClassOf NCIT_C119743 @default.
- NCIT_C119743 subClassOf NCIT_C129824 @default.
- NCIT_C119743 subClassOf NCIT_C1908 @default.
- NCIT_C119743 subClassOf NCIT_C1909 @default.
- NCIT_C119743 subClassOf NCIT_C2189 @default.
- NCIT_C119743 subClassOf NCIT_C274 @default.
- NCIT_C119743 subClassOf NCIT_C29750 @default.
- NCIT_C119743 subClassOf NCIT_C78275 @default.