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- NCIT_C119744 IAO_0000115 "An orally bioavailable recombinant human immunoglobulin G1 monoclonal antibody directed against human fibroblast growth factor 23 (FGF23), that can be used to increase serum phosphate levels. Upon subcutaneous administration, burosumab binds to and inhibits FGF23, thereby interfering with FGF23 signaling. This increases tubular phosphate reabsorption, decreases excretion of phosphate, and increases serum phosphate levels, resulting in enhanced bone mineralization. FGF23, a member of the fibroblast growth factor (FGF) family produced by osteocytes, plays a key role in hypophosphatemic rickets/osteomalacia, such as X-linked hypophosphatemia (XLH) and tumor-induced rickets/osteomalacia. Increased FGF23 levels lead to decreased expression of the sodium-phosphate co-transporters in the proximal tubules, reduced renal phosphate reabsorption, increased excretion by the kidneys, and low serum phosphate concentration." @default.
- NCIT_C119744 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119744 NCIT_A7 NCIT_C104384 @default.
- NCIT_C119744 NCIT_NHC0 "C119744" @default.
- NCIT_C119744 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C119744 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C119744 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119744 NCIT_P107 "Burosumab" @default.
- NCIT_C119744 NCIT_P108 "Burosumab" @default.
- NCIT_C119744 NCIT_P207 "C3896830" @default.
- NCIT_C119744 NCIT_P210 "1610833-03-8" @default.
- NCIT_C119744 NCIT_P319 "G9WJT6RD29" @default.
- NCIT_C119744 NCIT_P322 "CTRP" @default.
- NCIT_C119744 NCIT_P322 "FDA" @default.
- NCIT_C119744 NCIT_P322 "GDC" @default.
- NCIT_C119744 NCIT_P329 "767123" @default.
- NCIT_C119744 NCIT_P330 "767123" @default.
- NCIT_C119744 NCIT_P375 "Burosumab" @default.
- NCIT_C119744 NCIT_P399 "767123" @default.
- NCIT_C119744 NCIT_R124 NCIT_C17710 @default.
- NCIT_C119744 NCIT_R124 NCIT_C17828 @default.
- NCIT_C119744 NCIT_R124 NCIT_C18219 @default.
- NCIT_C119744 NCIT_R124 NCIT_C19986 @default.
- NCIT_C119744 NCIT_R124 NCIT_C40474 @default.
- NCIT_C119744 normalizedInformationContent "100" @default.
- NCIT_C119744 referenceCount "1" @default.
- NCIT_C119744 hasExactSynonym "Anti-FGF23 IgG1 Monoclonal Antibody KRN23" @default.
- NCIT_C119744 hasExactSynonym "BUROSUMAB" @default.
- NCIT_C119744 hasExactSynonym "Burosumab" @default.
- NCIT_C119744 hasExactSynonym "Burosumab-TWZA" @default.
- NCIT_C119744 hasExactSynonym "Crysvita" @default.
- NCIT_C119744 hasExactSynonym "KRN23" @default.
- NCIT_C119744 hasExactSynonym "UX023" @default.
- NCIT_C119744 inSubset NCIT_C116977 @default.
- NCIT_C119744 inSubset NCIT_C116978 @default.
- NCIT_C119744 inSubset NCIT_C128784 @default.
- NCIT_C119744 inSubset NCIT_C157711 @default.
- NCIT_C119744 inSubset NCIT_C157712 @default.
- NCIT_C119744 inSubset NCIT_C176424 @default.
- NCIT_C119744 inSubset NCIT_C177537 @default.
- NCIT_C119744 inSubset NCIT_C63923 @default.
- NCIT_C119744 type Class @default.
- NCIT_C119744 isDefinedBy ncit.owl @default.
- NCIT_C119744 label "Burosumab" @default.
- NCIT_C119744 subClassOf B301285c72c574817f1f0d6a7b0be5f8d @default.
- NCIT_C119744 subClassOf B51b62186b347db5a2af44050abed63f0 @default.
- NCIT_C119744 subClassOf NCIT_C119744 @default.
- NCIT_C119744 subClassOf NCIT_C129821 @default.
- NCIT_C119744 subClassOf NCIT_C129822 @default.
- NCIT_C119744 subClassOf NCIT_C1908 @default.
- NCIT_C119744 subClassOf NCIT_C1909 @default.
- NCIT_C119744 subClassOf NCIT_C20401 @default.
- NCIT_C119744 subClassOf NCIT_C274 @default.
- NCIT_C119744 subClassOf NCIT_C307 @default.
- NCIT_C119744 subClassOf NCIT_C308 @default.