Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C119746> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- NCIT_C119746 IAO_0000115 "A preparation of genetically modified autologous human T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the L1 cell adhesion molecule (L1-CAM/CD171) antigen, and the co-stimulatory signaling domains CD28, 4-1BB (CD137) and CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the autologous L1-CAM-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T-lymphocytes are directed to and induce selective toxicity in L1-CAM-expressing tumor cells. L1-CAM, a neuronal cell adhesion molecule and member of the L1 protein family, plays a key role in the development of the nervous system; it is overexpressed in various tumor cell types and is associated with increased chemoresistance, tumor progression, migration and metastasis. Devoid of both ligand-binding domains and tyrosine kinase activity, EGFRt facilitates both the detection of the administered T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The co-stimulatory signaling domains enhance both proliferation of T-cells and antitumor activity." @default.
- NCIT_C119746 NCIT_NHC0 "C119746" @default.
- NCIT_C119746 NCIT_P106 "Cell" @default.
- NCIT_C119746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119746 NCIT_P107 "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C119746 NCIT_P108 "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C119746 NCIT_P207 "C3900004" @default.
- NCIT_C119746 NCIT_P322 "CTRP" @default.
- NCIT_C119746 NCIT_P329 "767199" @default.
- NCIT_C119746 NCIT_P330 "767199" @default.
- NCIT_C119746 NCIT_P399 "767199" @default.
- NCIT_C119746 NCIT_R124 NCIT_C17828 @default.
- NCIT_C119746 NCIT_R124 NCIT_C17930 @default.
- NCIT_C119746 NCIT_R124 NCIT_C17937 @default.
- NCIT_C119746 NCIT_R124 NCIT_C18839 @default.
- NCIT_C119746 NCIT_R124 NCIT_C21124 @default.
- NCIT_C119746 NCIT_R124 NCIT_C45548 @default.
- NCIT_C119746 NCIT_R125 NCIT_C17828 @default.
- NCIT_C119746 NCIT_R125 NCIT_C17937 @default.
- NCIT_C119746 NCIT_R125 NCIT_C18095 @default.
- NCIT_C119746 NCIT_R125 NCIT_C18839 @default.
- NCIT_C119746 NCIT_R125 NCIT_C19053 @default.
- NCIT_C119746 NCIT_R125 NCIT_C21124 @default.
- NCIT_C119746 NCIT_R125 NCIT_C26280 @default.
- NCIT_C119746 NCIT_R125 NCIT_C40833 @default.
- NCIT_C119746 NCIT_R125 NCIT_C40912 @default.
- NCIT_C119746 NCIT_R72 NCIT_C104083 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12219 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12476 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12508 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12535 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12542 @default.
- NCIT_C119746 NCIT_R72 NCIT_C12543 @default.
- NCIT_C119746 NCIT_R72 NCIT_C21599 @default.
- NCIT_C119746 NCIT_R72 NCIT_C32725 @default.
- NCIT_C119746 NCIT_R72 NCIT_C33061 @default.
- NCIT_C119746 NCIT_R72 NCIT_C38434 @default.
- NCIT_C119746 NCIT_R72 NCIT_C38439 @default.
- NCIT_C119746 NCIT_R72 NCIT_C39567 @default.
- NCIT_C119746 NCIT_R72 NCIT_C39568 @default.
- NCIT_C119746 normalizedInformationContent "100" @default.
- NCIT_C119746 referenceCount "1" @default.
- NCIT_C119746 hasExactSynonym "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C119746 hasExactSynonym "CD171 CAR+ T Cells" @default.
- NCIT_C119746 hasExactSynonym "CE7R CAR T Cells" @default.
- NCIT_C119746 inSubset NCIT_C116977 @default.
- NCIT_C119746 inSubset NCIT_C116978 @default.
- NCIT_C119746 inSubset NCIT_C128784 @default.
- NCIT_C119746 inSubset NCIT_C176424 @default.
- NCIT_C119746 type Class @default.
- NCIT_C119746 isDefinedBy ncit.owl @default.
- NCIT_C119746 label "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C119746 subClassOf NCIT_C119746 @default.
- NCIT_C119746 subClassOf NCIT_C129820 @default.
- NCIT_C119746 subClassOf NCIT_C129821 @default.
- NCIT_C119746 subClassOf NCIT_C129826 @default.
- NCIT_C119746 subClassOf NCIT_C137999 @default.
- NCIT_C119746 subClassOf NCIT_C142078 @default.
- NCIT_C119746 subClassOf NCIT_C154231 @default.
- NCIT_C119746 subClassOf NCIT_C1908 @default.
- NCIT_C119746 subClassOf NCIT_C1909 @default.
- NCIT_C119746 subClassOf NCIT_C1962 @default.
- NCIT_C119746 subClassOf NCIT_C200766 @default.
- NCIT_C119746 subClassOf NCIT_C274 @default.
- NCIT_C119746 subClassOf NCIT_C28681 @default.
- NCIT_C119746 subClassOf NCIT_C307 @default.
- NCIT_C119746 subClassOf NCIT_C308 @default.