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- NCIT_C119747 IAO_0000115 "An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, CC-90003 inhibits ERK activity, and prevents the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C119747 NCIT_A32 NCIT_C1909 @default.
- NCIT_C119747 NCIT_A7 NCIT_C16376 @default.
- NCIT_C119747 NCIT_NHC0 "C119747" @default.
- NCIT_C119747 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119747 NCIT_P107 "ERK Inhibitor CC-90003" @default.
- NCIT_C119747 NCIT_P108 "ERK Inhibitor CC-90003" @default.
- NCIT_C119747 NCIT_P207 "C3896889" @default.
- NCIT_C119747 NCIT_P322 "CTRP" @default.
- NCIT_C119747 NCIT_P322 "GDC" @default.
- NCIT_C119747 NCIT_P329 "767257" @default.
- NCIT_C119747 NCIT_P330 "767257" @default.
- NCIT_C119747 NCIT_P375 "ERK Inhibitor CC-90003" @default.
- NCIT_C119747 NCIT_P399 "767257" @default.
- NCIT_C119747 normalizedInformationContent "100" @default.
- NCIT_C119747 referenceCount "1" @default.
- NCIT_C119747 hasExactSynonym "CC-90003" @default.
- NCIT_C119747 hasExactSynonym "ERK Inhibitor CC-90003" @default.
- NCIT_C119747 inSubset NCIT_C116977 @default.
- NCIT_C119747 inSubset NCIT_C116978 @default.
- NCIT_C119747 inSubset NCIT_C128784 @default.
- NCIT_C119747 inSubset NCIT_C157711 @default.
- NCIT_C119747 inSubset NCIT_C157712 @default.
- NCIT_C119747 inSubset NCIT_C176424 @default.
- NCIT_C119747 inSubset NCIT_C177537 @default.
- NCIT_C119747 type Class @default.
- NCIT_C119747 isDefinedBy ncit.owl @default.
- NCIT_C119747 label "ERK Inhibitor CC-90003" @default.
- NCIT_C119747 subClassOf NCIT_C119747 @default.
- NCIT_C119747 subClassOf NCIT_C129824 @default.
- NCIT_C119747 subClassOf NCIT_C129825 @default.
- NCIT_C119747 subClassOf NCIT_C1404 @default.
- NCIT_C119747 subClassOf NCIT_C174048 @default.
- NCIT_C119747 subClassOf NCIT_C1908 @default.
- NCIT_C119747 subClassOf NCIT_C1909 @default.
- NCIT_C119747 subClassOf NCIT_C2189 @default.
- NCIT_C119747 subClassOf NCIT_C274 @default.
- NCIT_C119747 subClassOf NCIT_C471 @default.
- NCIT_C119747 subClassOf NCIT_C61074 @default.