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- NCIT_C119952 IAO_0000115 "A monoclonal antibody against mannan-binding lectin (MBL)-associated serine protease-2 (MASP-2), with potential anti-thrombotic and immunomodulating activities. Upon subcutaneous administration, narsoplimab binds to and inhibits MASP-2. This prevents the activation of MASP-2, the cleavage of certain complement components, and the activation of the complement lectin pathway. This inhibits complement deposition and complement-induced thrombus formation. MASP-2, a pro-inflammatory protein, plays a key role in the activation of the lectin complement pathway, which is a key component in the immune system, and is associated with complement-mediated diseases, such as thrombotic microangiopathies (TMAs), which includes hematopoietic stem cell transplant (HSCT)-related TMA, atypical hemolytic uremic syndrome (aHUS), and thrombotic thrombocytopenic purpura (TTP)." @default.
- NCIT_C119952 NCIT_A7 NCIT_C181978 @default.
- NCIT_C119952 NCIT_NHC0 "C119952" @default.
- NCIT_C119952 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C119952 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C119952 NCIT_P107 "Anti-MASP-2 Monoclonal Antibody OMS721" @default.
- NCIT_C119952 NCIT_P108 "Narsoplimab" @default.
- NCIT_C119952 NCIT_P207 "C3896796" @default.
- NCIT_C119952 NCIT_P210 "2108782-45-0" @default.
- NCIT_C119952 NCIT_P319 "FT24ZQQ5RP" @default.
- NCIT_C119952 NCIT_P322 "CTRP" @default.
- NCIT_C119952 NCIT_P322 "FDA" @default.
- NCIT_C119952 NCIT_P329 "773678" @default.
- NCIT_C119952 NCIT_P330 "773678" @default.
- NCIT_C119952 NCIT_P399 "773678" @default.
- NCIT_C119952 NCIT_R124 NCIT_C17710 @default.
- NCIT_C119952 NCIT_R124 NCIT_C17828 @default.
- NCIT_C119952 NCIT_R124 NCIT_C18219 @default.
- NCIT_C119952 NCIT_R124 NCIT_C19986 @default.
- NCIT_C119952 NCIT_R124 NCIT_C40474 @default.
- NCIT_C119952 normalizedInformationContent "100" @default.
- NCIT_C119952 referenceCount "1" @default.
- NCIT_C119952 hasExactSynonym "Anti-MASP-2 Monoclonal Antibody OMS721" @default.
- NCIT_C119952 hasExactSynonym "NARSOPLIMAB" @default.
- NCIT_C119952 hasExactSynonym "Narsoplimab" @default.
- NCIT_C119952 hasExactSynonym "OMS721" @default.
- NCIT_C119952 hasExactSynonym "WHO 11174" @default.
- NCIT_C119952 inSubset NCIT_C116977 @default.
- NCIT_C119952 inSubset NCIT_C116978 @default.
- NCIT_C119952 inSubset NCIT_C176424 @default.
- NCIT_C119952 inSubset NCIT_C63923 @default.
- NCIT_C119952 type Class @default.
- NCIT_C119952 isDefinedBy ncit.owl @default.
- NCIT_C119952 label "Narsoplimab" @default.
- NCIT_C119952 subClassOf NCIT_C119952 @default.
- NCIT_C119952 subClassOf NCIT_C1908 @default.
- NCIT_C119952 subClassOf NCIT_C1909 @default.
- NCIT_C119952 subClassOf NCIT_C20401 @default.
- NCIT_C119952 subClassOf NCIT_C307 @default.
- NCIT_C119952 subClassOf NCIT_C308 @default.