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- NCIT_C1200 IAO_0000115 "A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. The agent also induces apoptosis in tumor cells. Pegylation decreases the enzyme's antigenicity. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. (NCI04)" @default.
- NCIT_C1200 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1200 NCIT_NHC0 "C1200" @default.
- NCIT_C1200 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1200 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1200 NCIT_P107 "Pegaspargase" @default.
- NCIT_C1200 NCIT_P108 "Pegaspargase" @default.
- NCIT_C1200 NCIT_P175 "624239" @default.
- NCIT_C1200 NCIT_P175 "644954" @default.
- NCIT_C1200 NCIT_P207 "C0071568" @default.
- NCIT_C1200 NCIT_P210 "130167-69-0" @default.
- NCIT_C1200 NCIT_P302 "Acute lymphoblastic leukemia" @default.
- NCIT_C1200 NCIT_P319 "7D96IR0PPM" @default.
- NCIT_C1200 NCIT_P322 "CTRP" @default.
- NCIT_C1200 NCIT_P322 "FDA" @default.
- NCIT_C1200 NCIT_P322 "GDC" @default.
- NCIT_C1200 NCIT_P325 "A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the drug asparaginase that is linked to a substance called PEG, which makes the drug stay in the body longer. Asparaginase is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor." @default.
- NCIT_C1200 NCIT_P329 "40312" @default.
- NCIT_C1200 NCIT_P330 "40312" @default.
- NCIT_C1200 NCIT_P366 "Pegaspargase" @default.
- NCIT_C1200 NCIT_P375 "Pegaspargase" @default.
- NCIT_C1200 NCIT_P399 "40312" @default.
- NCIT_C1200 normalizedInformationContent "73.363595225044847" @default.
- NCIT_C1200 referenceCount "56" @default.
- NCIT_C1200 hasExactSynonym "(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase" @default.
- NCIT_C1200 hasExactSynonym "L-Asparaginase with Polyethylene Glycol" @default.
- NCIT_C1200 hasExactSynonym "Oncaspar" @default.
- NCIT_C1200 hasExactSynonym "Oncaspar-IV" @default.
- NCIT_C1200 hasExactSynonym "PEG-Asparaginase" @default.
- NCIT_C1200 hasExactSynonym "PEG-L-Asparaginase (Enzon - Kyowa Hakko)" @default.
- NCIT_C1200 hasExactSynonym "PEG-L-Asparaginase" @default.
- NCIT_C1200 hasExactSynonym "PEG-asparaginase" @default.
- NCIT_C1200 hasExactSynonym "PEGASPARGASE" @default.
- NCIT_C1200 hasExactSynonym "PEGLA" @default.
- NCIT_C1200 hasExactSynonym "Pegaspargase" @default.
- NCIT_C1200 hasExactSynonym "Polyethylene Glycol L-Asparaginase" @default.
- NCIT_C1200 hasExactSynonym "Polyethylene Glycol-L-Asparaginase" @default.
- NCIT_C1200 hasExactSynonym "pegaspargase" @default.
- NCIT_C1200 inSubset NCIT_C116977 @default.
- NCIT_C1200 inSubset NCIT_C116978 @default.
- NCIT_C1200 inSubset NCIT_C128784 @default.
- NCIT_C1200 inSubset NCIT_C157711 @default.
- NCIT_C1200 inSubset NCIT_C157712 @default.
- NCIT_C1200 inSubset NCIT_C176424 @default.
- NCIT_C1200 inSubset NCIT_C177537 @default.
- NCIT_C1200 inSubset NCIT_C63923 @default.
- NCIT_C1200 type Class @default.
- NCIT_C1200 isDefinedBy ncit.owl @default.
- NCIT_C1200 label "Pegaspargase" @default.
- NCIT_C1200 subClassOf NCIT_C1200 @default.
- NCIT_C1200 subClassOf NCIT_C177280 @default.
- NCIT_C1200 subClassOf NCIT_C177430 @default.
- NCIT_C1200 subClassOf NCIT_C1908 @default.
- NCIT_C1200 subClassOf NCIT_C1909 @default.
- NCIT_C1200 subClassOf NCIT_C274 @default.
- NCIT_C1200 subClassOf NCIT_C29726 @default.
- NCIT_C1200 subClassOf NCIT_C307 @default.