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- NCIT_C120004 IAO_0000115 "An ester or salt of the bile acid cholic acid that is synthesized in the liver from cholesterol, with surfactant and signaling activities in the liver and intestine. In the intestine, cholate acts as a surfactant that promotes the absorption of dietary lipids and fat-soluble vitamins. In the liver, cholate's surfactant activity facilitates biliary excretion of xenobiotics and metal cations. Cholate binds to nuclear receptors, including farnesoid X receptor (FXR), pregnane X receptor (PXR), and the vitamin D receptor (VDR), which directly modulate gene transcription. Cholate may also be used as a biomarker for hepatotoxicity." @default.
- NCIT_C120004 NCIT_NHC0 "C120004" @default.
- NCIT_C120004 NCIT_P106 "Organic Chemical" @default.
- NCIT_C120004 NCIT_P107 "Cholate" @default.
- NCIT_C120004 NCIT_P108 "Cholate" @default.
- NCIT_C120004 NCIT_P207 "C0109497" @default.
- NCIT_C120004 NCIT_P322 "CTRP" @default.
- NCIT_C120004 NCIT_P368 "CHEBI:29747" @default.
- NCIT_C120004 normalizedInformationContent "100" @default.
- NCIT_C120004 referenceCount "1" @default.
- NCIT_C120004 hasExactSynonym "3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholan-24-Oate" @default.
- NCIT_C120004 hasExactSynonym "3alpha,7alpha,12alpha-Trihydroxy-5beta-Cholanate" @default.
- NCIT_C120004 hasExactSynonym "Cholate" @default.
- NCIT_C120004 inSubset NCIT_C116977 @default.
- NCIT_C120004 inSubset NCIT_C142799 @default.
- NCIT_C120004 type Class @default.
- NCIT_C120004 isDefinedBy ncit.owl @default.
- NCIT_C120004 label "Cholate" @default.
- NCIT_C120004 subClassOf NCIT_C120004 @default.
- NCIT_C120004 subClassOf NCIT_C1908 @default.
- NCIT_C120004 subClassOf NCIT_C1909 @default.
- NCIT_C120004 subClassOf NCIT_C66913 @default.
- NCIT_C120004 subClassOf NCIT_C78276 @default.