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- NCIT_C120039 IAO_0000115 "An individualized, therapeutic cancer vaccine (IVAC) composed of liposomes containing RNA encoding two or three tumor associated antigens (TAAs) that are specifically expressed in the patient's individual cancer selected from a warehouse ("off the shelf") and p53 RNA, with potential immunostimulatory and antineoplastic activities. Upon administration, the antigen-targeted personalized breast cancer vaccines are translated by antigen presenting cells (APCs) and the expressed protein is presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL) and memory T-cell immune responses against the TAAs. The RNAs in the vaccine are specifically selected for an individual patient after RNA profiling of the patient's tumor." @default.
- NCIT_C120039 NCIT_NHC0 "C120039" @default.
- NCIT_C120039 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120039 NCIT_P108 "Antigen-targeted Personalized Breast Cancer Vaccine" @default.
- NCIT_C120039 NCIT_P207 "C3900022" @default.
- NCIT_C120039 NCIT_P329 "767426" @default.
- NCIT_C120039 NCIT_P330 "767426" @default.
- NCIT_C120039 NCIT_P399 "767426" @default.
- NCIT_C120039 normalizedInformationContent "100" @default.
- NCIT_C120039 referenceCount "1" @default.
- NCIT_C120039 hasExactSynonym "Antigen-targeted Personalized Breast Cancer Vaccine" @default.
- NCIT_C120039 hasExactSynonym "IVAC_W_bre1_uID" @default.
- NCIT_C120039 inSubset NCIT_C128784 @default.
- NCIT_C120039 inSubset NCIT_C176424 @default.
- NCIT_C120039 type Class @default.
- NCIT_C120039 isDefinedBy ncit.owl @default.
- NCIT_C120039 label "Antigen-targeted Personalized Breast Cancer Vaccine" @default.
- NCIT_C120039 subClassOf NCIT_C120039 @default.
- NCIT_C120039 subClassOf NCIT_C129820 @default.
- NCIT_C120039 subClassOf NCIT_C1663 @default.
- NCIT_C120039 subClassOf NCIT_C172787 @default.
- NCIT_C120039 subClassOf NCIT_C181141 @default.
- NCIT_C120039 subClassOf NCIT_C1908 @default.
- NCIT_C120039 subClassOf NCIT_C1909 @default.
- NCIT_C120039 subClassOf NCIT_C274 @default.
- NCIT_C120039 subClassOf NCIT_C307 @default.
- NCIT_C120039 subClassOf NCIT_C308 @default.
- NCIT_C120039 subClassOf NCIT_C923 @default.