Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C120040> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- NCIT_C120040 IAO_0000115 "A glycoengineered, humanized monoclonal antibody directed against the fibroblast growth factor receptor type 2b (FGFR2b), with potential antineoplastic activity. Upon administration, bemarituzumab specifically binds to and inhibits FGFR2b on tumor cell surfaces, which prevents FGFR2 from binding to its ligands, FGFR2b activation and the activation of FGFR2b-mediated signal transduction pathways. The binding of FPA144 to FGFR2b protein also induces antibody-dependent cell-mediated cytotoxicity (ADCC) against FGFR2b-expressing tumor cells. This results in the inhibition of cell proliferation and the induction of cell death of FGFR2-expressing tumor cells. FGFR2b, a specific isoform of the receptor tyrosine kinase FGFR2 upregulated in many tumor cell types, is essential to tumor proliferation, differentiation and survival. Glycoengineering enhances the FPA144-mediated ADCC." @default.
- NCIT_C120040 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120040 NCIT_A7 NCIT_C124074 @default.
- NCIT_C120040 NCIT_NHC0 "C120040" @default.
- NCIT_C120040 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C120040 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120040 NCIT_P107 "Bemarituzumab" @default.
- NCIT_C120040 NCIT_P108 "Bemarituzumab" @default.
- NCIT_C120040 NCIT_P207 "C3896858" @default.
- NCIT_C120040 NCIT_P210 "1952272-74-0" @default.
- NCIT_C120040 NCIT_P319 "RJW23BQ0KW" @default.
- NCIT_C120040 NCIT_P322 "CTRP" @default.
- NCIT_C120040 NCIT_P322 "FDA" @default.
- NCIT_C120040 NCIT_P322 "GDC" @default.
- NCIT_C120040 NCIT_P329 "767461" @default.
- NCIT_C120040 NCIT_P330 "767461" @default.
- NCIT_C120040 NCIT_P375 "Bemarituzumab" @default.
- NCIT_C120040 NCIT_P399 "767461" @default.
- NCIT_C120040 NCIT_R124 NCIT_C17710 @default.
- NCIT_C120040 NCIT_R124 NCIT_C17828 @default.
- NCIT_C120040 NCIT_R124 NCIT_C18219 @default.
- NCIT_C120040 NCIT_R124 NCIT_C19986 @default.
- NCIT_C120040 NCIT_R124 NCIT_C40474 @default.
- NCIT_C120040 normalizedInformationContent "100" @default.
- NCIT_C120040 referenceCount "1" @default.
- NCIT_C120040 hasExactSynonym "BEMARITUZUMAB" @default.
- NCIT_C120040 hasExactSynonym "Bemarituzumab" @default.
- NCIT_C120040 hasExactSynonym "FPA144" @default.
- NCIT_C120040 inSubset NCIT_C116977 @default.
- NCIT_C120040 inSubset NCIT_C116978 @default.
- NCIT_C120040 inSubset NCIT_C128784 @default.
- NCIT_C120040 inSubset NCIT_C157711 @default.
- NCIT_C120040 inSubset NCIT_C157712 @default.
- NCIT_C120040 inSubset NCIT_C176424 @default.
- NCIT_C120040 inSubset NCIT_C177537 @default.
- NCIT_C120040 inSubset NCIT_C63923 @default.
- NCIT_C120040 type Class @default.
- NCIT_C120040 isDefinedBy ncit.owl @default.
- NCIT_C120040 label "Bemarituzumab" @default.
- NCIT_C120040 subClassOf NCIT_C120040 @default.
- NCIT_C120040 subClassOf NCIT_C129821 @default.
- NCIT_C120040 subClassOf NCIT_C129822 @default.
- NCIT_C120040 subClassOf NCIT_C133879 @default.
- NCIT_C120040 subClassOf NCIT_C163758 @default.
- NCIT_C120040 subClassOf NCIT_C164035 @default.
- NCIT_C120040 subClassOf NCIT_C1908 @default.
- NCIT_C120040 subClassOf NCIT_C1909 @default.
- NCIT_C120040 subClassOf NCIT_C20401 @default.
- NCIT_C120040 subClassOf NCIT_C274 @default.
- NCIT_C120040 subClassOf NCIT_C307 @default.
- NCIT_C120040 subClassOf NCIT_C308 @default.