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- NCIT_C120042 IAO_0000115 "A nutritional supplement enriched with eicosapentaenoic acid (EPA), which is an essential, polyunsaturated, 20-carbon omega-3 fatty acid found in fish oil, with potential anti-inflammatory and anti-cachectic activities. Upon oral intake of the EPA-enriched nutritional supplement, EPA is incorporated in cell membrane phospholipids and replaces arachidonic acid. This affects the production of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-a), interleukin-1 (IL-1) and IL-6, through the inhibition of nuclear factor kappa B (NF-kB) activity. This inhibits inflammation and may abrogate the cachexia-mediated decrease of lean body mass (LBM), which may lead to increased body weight. Pro-inflammatory mediators, such as TNF-a, interferon-gamma, and certain interleukins, such as IL-6 and IL-1b, play a key role in cachexia." @default.
- NCIT_C120042 NCIT_NHC0 "C120042" @default.
- NCIT_C120042 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120042 NCIT_P108 "Eicosapentaenoic Acid-enriched Nutritional Supplement" @default.
- NCIT_C120042 NCIT_P207 "C3899275" @default.
- NCIT_C120042 NCIT_P329 "767628" @default.
- NCIT_C120042 NCIT_P330 "767628" @default.
- NCIT_C120042 NCIT_P399 "767628" @default.
- NCIT_C120042 normalizedInformationContent "100" @default.
- NCIT_C120042 referenceCount "1" @default.
- NCIT_C120042 hasExactSynonym "EPA-enriched Nutritional Supplement" @default.
- NCIT_C120042 hasExactSynonym "Eicosapentaenoic Acid-enriched Nutritional Supplement" @default.
- NCIT_C120042 inSubset NCIT_C128784 @default.
- NCIT_C120042 inSubset NCIT_C176424 @default.
- NCIT_C120042 type Class @default.
- NCIT_C120042 isDefinedBy ncit.owl @default.
- NCIT_C120042 label "Eicosapentaenoic Acid-enriched Nutritional Supplement" @default.
- NCIT_C120042 subClassOf NCIT_C120042 @default.
- NCIT_C120042 subClassOf NCIT_C1505 @default.
- NCIT_C120042 subClassOf NCIT_C1908 @default.