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- NCIT_C120068 IAO_0000115 "A lyophilized formulation of DOS47, an immunoconjugate composed of AFAIKL2, a recombinant camelid single-domain antibody which recognizes carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), and the enzyme urease derived from the plant Canavalia ensiformis (Jack bean), with potential antineoplastic activity. Upon intravenous administration, the AFAIKL2 antibody fragment moiety of L-DOS47 specifically targets and binds to CEACAM6 expressed on certain tumor cells. In turn, the urease moiety of L-DOS47 catalyzes the hydrolysis of urea into ammonia, which is further hydrolyzed to produce hydroxyl ions, and causes a locally increased concentration of the toxic waste product ammonia, which under normal conditions is converted into the nontoxic substance urea via the urea cycle. This increases the pH of the tumor microenvironment and alkalinizes the highly acidic environment that is needed for cancer cell survival and proliferation. In addition, the ammonia diffuses into cancer cells and exerts a cytotoxic effect. Altogether, this leads to cell death of CEACAM6-expressing cancer cells. The naturally-occurring enzyme urease catalyzes the hydrolysis of urea into ammonia and carbon dioxide. CEACAM6, a tumor-associated antigen and CEA family member, is overexpressed in a variety of tumor cells and plays a key role in tumor initiation, progression, metastasis and survival." @default.
- NCIT_C120068 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120068 NCIT_A7 NCIT_C107471 @default.
- NCIT_C120068 NCIT_NHC0 "C120068" @default.
- NCIT_C120068 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120068 NCIT_P107 "Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47" @default.
- NCIT_C120068 NCIT_P108 "Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47" @default.
- NCIT_C120068 NCIT_P207 "C3896827" @default.
- NCIT_C120068 NCIT_P319 "95E1ZQM329" @default.
- NCIT_C120068 NCIT_P322 "CTRP" @default.
- NCIT_C120068 NCIT_P322 "FDA" @default.
- NCIT_C120068 NCIT_P322 "GDC" @default.
- NCIT_C120068 NCIT_P329 "768359" @default.
- NCIT_C120068 NCIT_P330 "768359" @default.
- NCIT_C120068 NCIT_P375 "Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47" @default.
- NCIT_C120068 NCIT_P399 "768359" @default.
- NCIT_C120068 normalizedInformationContent "100" @default.
- NCIT_C120068 referenceCount "1" @default.
- NCIT_C120068 hasExactSynonym "Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47" @default.
- NCIT_C120068 hasExactSynonym "L-DOS47" @default.
- NCIT_C120068 inSubset NCIT_C116977 @default.
- NCIT_C120068 inSubset NCIT_C116978 @default.
- NCIT_C120068 inSubset NCIT_C128784 @default.
- NCIT_C120068 inSubset NCIT_C157711 @default.
- NCIT_C120068 inSubset NCIT_C157712 @default.
- NCIT_C120068 inSubset NCIT_C176424 @default.
- NCIT_C120068 inSubset NCIT_C177537 @default.
- NCIT_C120068 inSubset NCIT_C63923 @default.
- NCIT_C120068 type Class @default.
- NCIT_C120068 isDefinedBy ncit.owl @default.
- NCIT_C120068 label "Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47" @default.
- NCIT_C120068 subClassOf NCIT_C120068 @default.
- NCIT_C120068 subClassOf NCIT_C129821 @default.
- NCIT_C120068 subClassOf NCIT_C129823 @default.
- NCIT_C120068 subClassOf NCIT_C1512 @default.
- NCIT_C120068 subClassOf NCIT_C1908 @default.
- NCIT_C120068 subClassOf NCIT_C1909 @default.
- NCIT_C120068 subClassOf NCIT_C274 @default.
- NCIT_C120068 subClassOf NCIT_C307 @default.
- NCIT_C120068 subClassOf NCIT_C308 @default.