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- NCIT_C1201 IAO_0000115 "A highly negative-charged carbohydrate composed of a linear polymer of alpha 2,8-linked sialic acid residue with potential immunotherapeutic activity. Polysialic acid (PSA) is mainly attached to the neural cell adhesion molecule (NCAM), a membrane-bound glycoprotein overexpressed in certain types of cancers. In embryonic tissue PSA-NCAM is abundantly expressed and PSA plays an important role in formation and remodeling of the neural system through modulation of the adhesive properties of NCAM, thereby reducing cell-cell interactions and promoting cellular mobility. In adult tissue however, the expression of PSA-NCAM is associated with a variety of malignant tumors, signifying its potential role in tumor metastasis. When administered in a vaccine formulation, PSA may stimulate a cytotoxic T cell response against tumors expressing PSA, thereby resulting in a reduction in tumor size." @default.
- NCIT_C1201 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1201 NCIT_NHC0 "C1201" @default.
- NCIT_C1201 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1201 NCIT_P108 "Polysialic Acid" @default.
- NCIT_C1201 NCIT_P207 "C0071677" @default.
- NCIT_C1201 NCIT_P322 "GDC" @default.
- NCIT_C1201 NCIT_P329 "37839" @default.
- NCIT_C1201 NCIT_P330 "37839" @default.
- NCIT_C1201 NCIT_P366 "Polysialic_Acid" @default.
- NCIT_C1201 NCIT_P368 "CHEBI:26206" @default.
- NCIT_C1201 NCIT_P375 "Polysialic Acid" @default.
- NCIT_C1201 NCIT_P399 "37839" @default.
- NCIT_C1201 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1201 referenceCount "3" @default.
- NCIT_C1201 hasExactSynonym "PolySA" @default.
- NCIT_C1201 hasExactSynonym "Polysialic Acid" @default.
- NCIT_C1201 inSubset NCIT_C128784 @default.
- NCIT_C1201 inSubset NCIT_C157711 @default.
- NCIT_C1201 inSubset NCIT_C157712 @default.
- NCIT_C1201 inSubset NCIT_C176424 @default.
- NCIT_C1201 inSubset NCIT_C177537 @default.
- NCIT_C1201 type Class @default.
- NCIT_C1201 isDefinedBy ncit.owl @default.
- NCIT_C1201 label "Polysialic Acid" @default.
- NCIT_C1201 subClassOf NCIT_C1201 @default.
- NCIT_C1201 subClassOf NCIT_C1908 @default.
- NCIT_C1201 subClassOf NCIT_C1909 @default.
- NCIT_C1201 subClassOf NCIT_C1913 @default.
- NCIT_C1201 subClassOf NCIT_C268 @default.
- NCIT_C1201 subClassOf NCIT_C28188 @default.
- NCIT_C1201 subClassOf NCIT_C307 @default.
- NCIT_C1201 subClassOf NCIT_C344 @default.
- NCIT_C1201 subClassOf NCIT_C718 @default.