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- NCIT_C120101 IAO_0000115 "A lipophilic, orally available inhibitor of both Src kinase activity and tubulin polymerization, with potential antineoplastic activity. Upon oral administration,Src/tubulin Inhibitor KX2-361 binds to and inhibits the activity of Src kinase. This inhibits both downstream signaling and the proliferation of Src kinase-expressing tumor cells. KX02 also binds to tubulin heterodimers and inhibits microtubule polymerization, thereby disrupting microtubule formation, mitosis, and further proliferation. Src, a non-receptor tyrosine kinase, is overexpressed in a variety of tumor cell types and plays a key role in tumor cell proliferation, angiogenesis, migration, and metastasis." @default.
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- NCIT_C120101 NCIT_A7 NCIT_C17389 @default.
- NCIT_C120101 NCIT_NHC0 "C120101" @default.
- NCIT_C120101 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120101 NCIT_P107 "Src/tubulin Inhibitor KX2-361" @default.
- NCIT_C120101 NCIT_P108 "Src/tubulin Inhibitor KX2-361" @default.
- NCIT_C120101 NCIT_P207 "C3896828" @default.
- NCIT_C120101 NCIT_P210 "897016-26-1" @default.
- NCIT_C120101 NCIT_P319 "RVW387BA9U" @default.
- NCIT_C120101 NCIT_P322 "CTRP" @default.
- NCIT_C120101 NCIT_P322 "FDA" @default.
- NCIT_C120101 NCIT_P322 "GDC" @default.
- NCIT_C120101 NCIT_P329 "767819" @default.
- NCIT_C120101 NCIT_P330 "767819" @default.
- NCIT_C120101 NCIT_P375 "Src/tubulin Inhibitor KX02" @default.
- NCIT_C120101 NCIT_P399 "767819" @default.
- NCIT_C120101 NCIT_R124 NCIT_C17828 @default.
- NCIT_C120101 NCIT_R124 NCIT_C20480 @default.
- NCIT_C120101 NCIT_R124 NCIT_C40795 @default.
- NCIT_C120101 NCIT_R124 NCIT_C40798 @default.
- NCIT_C120101 normalizedInformationContent "100" @default.
- NCIT_C120101 referenceCount "1" @default.
- NCIT_C120101 hasExactSynonym "KX02" @default.
- NCIT_C120101 hasExactSynonym "KX2-361" @default.
- NCIT_C120101 hasExactSynonym "Src/tubulin Inhibitor KX02" @default.
- NCIT_C120101 hasExactSynonym "Src/tubulin Inhibitor KX2-361" @default.
- NCIT_C120101 inSubset NCIT_C116977 @default.
- NCIT_C120101 inSubset NCIT_C116978 @default.
- NCIT_C120101 inSubset NCIT_C128784 @default.
- NCIT_C120101 inSubset NCIT_C157711 @default.
- NCIT_C120101 inSubset NCIT_C157712 @default.
- NCIT_C120101 inSubset NCIT_C176424 @default.
- NCIT_C120101 inSubset NCIT_C177537 @default.
- NCIT_C120101 inSubset NCIT_C63923 @default.
- NCIT_C120101 type Class @default.
- NCIT_C120101 isDefinedBy ncit.owl @default.
- NCIT_C120101 label "Src/tubulin Inhibitor KX2-361" @default.
- NCIT_C120101 subClassOf NCIT_C120101 @default.
- NCIT_C120101 subClassOf NCIT_C1404 @default.
- NCIT_C120101 subClassOf NCIT_C186664 @default.
- NCIT_C120101 subClassOf NCIT_C1908 @default.
- NCIT_C120101 subClassOf NCIT_C1909 @default.
- NCIT_C120101 subClassOf NCIT_C1967 @default.
- NCIT_C120101 subClassOf NCIT_C25974 @default.
- NCIT_C120101 subClassOf NCIT_C273 @default.
- NCIT_C120101 subClassOf NCIT_C274 @default.
- NCIT_C120101 subClassOf NCIT_C471 @default.