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- NCIT_C120103 IAO_0000115 "A cancer vaccine containing a live-attenuated strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding a fusion protein composed of the tumor-associated antigen (TAA) human prostate-specific antigen (PSA) fused to a fragment of the immunostimulant listeriolysin O (LLO) protein, with potential immunostimulatory and antineoplastic activities. Upon administration of the Lm-LLO-PSA vaccine ADXS31-142, the expressed LLO-PSA is processed by antigen presenting cells (APCs), presented to the immune system by both major histocompatibility complex (MHC) I and II molecules, and activates the immune system to exert both an innate and adaptive immune response involving the recruitment and activation of T-lymphocytes against PSA-expressing tumor cells as well as the inhibition of tumor-infiltrating T regulatory cells (T regs) and myeloid-derived suppressor cells (MDSCs). This eventually results in tumor cell lysis." @default.
- NCIT_C120103 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120103 NCIT_A7 NCIT_C17525 @default.
- NCIT_C120103 NCIT_NHC0 "C120103" @default.
- NCIT_C120103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120103 NCIT_P107 "Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142" @default.
- NCIT_C120103 NCIT_P108 "Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142" @default.
- NCIT_C120103 NCIT_P207 "C3896925" @default.
- NCIT_C120103 NCIT_P322 "CTRP" @default.
- NCIT_C120103 NCIT_P322 "GDC" @default.
- NCIT_C120103 NCIT_P329 "767990" @default.
- NCIT_C120103 NCIT_P330 "767990" @default.
- NCIT_C120103 NCIT_P375 "Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142" @default.
- NCIT_C120103 NCIT_P399 "767990" @default.
- NCIT_C120103 normalizedInformationContent "100" @default.
- NCIT_C120103 referenceCount "1" @default.
- NCIT_C120103 hasExactSynonym "ADXS-PSA" @default.
- NCIT_C120103 hasExactSynonym "ADXS31-142" @default.
- NCIT_C120103 hasExactSynonym "Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142" @default.
- NCIT_C120103 hasExactSynonym "Lm-LLO-PSA" @default.
- NCIT_C120103 inSubset NCIT_C116977 @default.
- NCIT_C120103 inSubset NCIT_C116978 @default.
- NCIT_C120103 inSubset NCIT_C128784 @default.
- NCIT_C120103 inSubset NCIT_C157711 @default.
- NCIT_C120103 inSubset NCIT_C157712 @default.
- NCIT_C120103 inSubset NCIT_C176424 @default.
- NCIT_C120103 inSubset NCIT_C177537 @default.
- NCIT_C120103 type Class @default.
- NCIT_C120103 isDefinedBy ncit.owl @default.
- NCIT_C120103 label "Listeria monocytogenes-LLO-PSA Vaccine ADXS31-142" @default.
- NCIT_C120103 subClassOf NCIT_C120103 @default.
- NCIT_C120103 subClassOf NCIT_C129820 @default.
- NCIT_C120103 subClassOf NCIT_C1663 @default.
- NCIT_C120103 subClassOf NCIT_C1908 @default.
- NCIT_C120103 subClassOf NCIT_C1909 @default.
- NCIT_C120103 subClassOf NCIT_C274 @default.
- NCIT_C120103 subClassOf NCIT_C307 @default.
- NCIT_C120103 subClassOf NCIT_C308 @default.
- NCIT_C120103 subClassOf NCIT_C923 @default.