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- NCIT_C120121 IAO_0000115 "A nutritional supplement containing essential branched-chain amino acids (BCAAs), including leucine, isoleucine and valine, with potential anti-cachectic, antiangiogenic, hepatocellular carcinoma (HCC) inhibiting and hepatoprotective activities. Upon oral administration, BCAAs inhibit the expression of both hypoxia-inducible factor 1-alpha subunit (HIF-1a) and vascular endothelial growth factor (VEGF), which prevents VEGF-mediated angiogenesis in HCC cells. In addition, BCAAs inhibit proliferation and induce apoptosis of HCC cells by both suppressing the expression of insulin-like growth factor (IGF), and inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. BCAAs also correct the plasma amino acid imbalance and promote protein metabolism, including the synthesis of albumin and glycogen. They reduce oxidative stress by inducing the activation of genes involved in antioxidant defenses, which prevent the production of reactive oxygen species (ROS). BCAAs also strengthen the immune system by increasing hepatic lymphocytes and stimulating natural killer (NK) cell activity. This supplement is able to improve insulin resistance and promote ammonia detoxification through increased glutamine (Gln) production." @default.
- NCIT_C120121 NCIT_NHC0 "C120121" @default.
- NCIT_C120121 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120121 NCIT_P108 "Branched-chain Amino Acid Supplement" @default.
- NCIT_C120121 NCIT_P207 "C3897130" @default.
- NCIT_C120121 NCIT_P329 "768009" @default.
- NCIT_C120121 NCIT_P330 "768009" @default.
- NCIT_C120121 NCIT_P399 "768009" @default.
- NCIT_C120121 normalizedInformationContent "100" @default.
- NCIT_C120121 referenceCount "1" @default.
- NCIT_C120121 hasExactSynonym "BCAA Supplement" @default.
- NCIT_C120121 hasExactSynonym "Branched-chain Amino Acid Supplement" @default.
- NCIT_C120121 inSubset NCIT_C128784 @default.
- NCIT_C120121 inSubset NCIT_C176424 @default.
- NCIT_C120121 type Class @default.
- NCIT_C120121 isDefinedBy ncit.owl @default.
- NCIT_C120121 label "Branched-chain Amino Acid Supplement" @default.
- NCIT_C120121 subClassOf NCIT_C120121 @default.
- NCIT_C120121 subClassOf NCIT_C1505 @default.
- NCIT_C120121 subClassOf NCIT_C1908 @default.