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- NCIT_C120209 IAO_0000115 "An orally available inhibitor of FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2) and the cyclin-dependent kinases 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon administration, FLT3/CDK4/6 inhibitor FLX925 specifically binds to and inhibits FLT3, which interferes with the activation of FLT3-mediated signal transduction pathways and reduces cell proliferation in cancer cells that overexpress FLT3. In addition FLX925 inhibits CDK4 and 6 and prevents the phosphorylation of retinoblastoma (Rb) protein in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, which causes G1 phase cell cycle arrest, suppresses DNA synthesis and inhibits cancer cell growth. FLT3, a class III tyrosine kinase receptor, is overexpressed in a variety of cancers. Overexpression of CDK4/6, which is seen in certain types of cancer, causes cell cycle deregulation." @default.
- NCIT_C120209 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120209 NCIT_A7 NCIT_C17680 @default.
- NCIT_C120209 NCIT_A7 NCIT_C26202 @default.
- NCIT_C120209 NCIT_A7 NCIT_C97386 @default.
- NCIT_C120209 NCIT_NHC0 "C120209" @default.
- NCIT_C120209 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120209 NCIT_P107 "FLT3/CDK4/6 Inhibitor FLX925" @default.
- NCIT_C120209 NCIT_P108 "FLT3/CDK4/6 Inhibitor FLX925" @default.
- NCIT_C120209 NCIT_P207 "C3896859" @default.
- NCIT_C120209 NCIT_P322 "CTRP" @default.
- NCIT_C120209 NCIT_P322 "GDC" @default.
- NCIT_C120209 NCIT_P329 "768269" @default.
- NCIT_C120209 NCIT_P330 "768269" @default.
- NCIT_C120209 NCIT_P375 "FLT3/CDK4/6 Inhibitor FLX925" @default.
- NCIT_C120209 NCIT_P399 "768269" @default.
- NCIT_C120209 normalizedInformationContent "100" @default.
- NCIT_C120209 referenceCount "1" @default.
- NCIT_C120209 hasExactSynonym "FLT3/CDK4/6 Inhibitor FLX925" @default.
- NCIT_C120209 hasExactSynonym "FLX925" @default.
- NCIT_C120209 inSubset NCIT_C116977 @default.
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- NCIT_C120209 inSubset NCIT_C176424 @default.
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- NCIT_C120209 type Class @default.
- NCIT_C120209 isDefinedBy ncit.owl @default.
- NCIT_C120209 label "FLT3/CDK4/6 Inhibitor FLX925" @default.
- NCIT_C120209 subClassOf NCIT_C120209 @default.
- NCIT_C120209 subClassOf NCIT_C124800 @default.
- NCIT_C120209 subClassOf NCIT_C129824 @default.
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- NCIT_C120209 subClassOf NCIT_C1967 @default.
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- NCIT_C120209 subClassOf NCIT_C274 @default.
- NCIT_C120209 subClassOf NCIT_C471 @default.
- NCIT_C120209 subClassOf NCIT_C61074 @default.