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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C120259> ?p ?o ?g. }

• NCIT_C120259 IAO_0000115 "The isethionate salt form of palbociclib, an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression." @default.
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• NCIT_C120259 NCIT_NHC0 "C120259" @default.
• NCIT_C120259 NCIT_P106 "Organic Chemical" @default.
• NCIT_C120259 NCIT_P106 "Pharmacologic Substance" @default.
• NCIT_C120259 NCIT_P107 "Palbociclib Isethionate" @default.
• NCIT_C120259 NCIT_P108 "Palbociclib Isethionate" @default.
• NCIT_C120259 NCIT_P207 "C3896941" @default.
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• NCIT_C120259 NCIT_P375 "Palbociclib Isethionate" @default.
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• NCIT_C120259 normalizedInformationContent "100" @default.
• NCIT_C120259 referenceCount "1" @default.
• NCIT_C120259 hasExactSynonym "6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino(pyrido(2,3-d)pyrimidin-7(8h)-one mono(2-hydroxyethanesulfonate)" @default.
• NCIT_C120259 hasExactSynonym "PALBOCICLIB ISETHIONATE" @default.
• NCIT_C120259 hasExactSynonym "PD 0332991-0054" @default.
• NCIT_C120259 hasExactSynonym "PF-00080665-73" @default.
• NCIT_C120259 hasExactSynonym "Palbociclib Isethionate" @default.
• NCIT_C120259 inSubset NCIT_C116977 @default.
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• NCIT_C120259 type Class @default.
• NCIT_C120259 isDefinedBy ncit.owl @default.
• NCIT_C120259 label "Palbociclib Isethionate" @default.
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• NCIT_C120259 subClassOf NCIT_C2185 @default.
• NCIT_C120259 subClassOf NCIT_C2189 @default.
• NCIT_C120259 subClassOf NCIT_C274 @default.

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