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- NCIT_C120304 IAO_0000115 "An orally available inhibitor of both the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17) and androgen receptor (AR), with potential anti-androgen and antineoplastic activities. Upon oral administration, CYP17/AR inhibitor ODM 204 selectively inhibits the enzymatic activity of CYP17A1 in both the testes and adrenal glands, thereby inhibiting androgen production. This may both decrease androgen-dependent growth signaling and inhibit the proliferation of androgen-dependent tumor cells. In addition, ODM 204 binds to ARs in target tissues and inhibits androgen-induced receptor activation and AR nuclear translocation, which prevents the binding to and transcription of AR-responsive genes. This leads to an inhibition of growth in AR-expressing prostate cancer cells. The cytochrome P450 enzyme CYP17A1, which is localized to the endoplasmic reticulum, exhibits both 17alpha-hydroxylase and 17,20-lyase activities." @default.
- NCIT_C120304 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120304 NCIT_NHC0 "C120304" @default.
- NCIT_C120304 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120304 NCIT_P108 "CYP17/Androgen Receptor Inhibitor ODM 204" @default.
- NCIT_C120304 NCIT_P207 "C3896798" @default.
- NCIT_C120304 NCIT_P322 "GDC" @default.
- NCIT_C120304 NCIT_P329 "768588" @default.
- NCIT_C120304 NCIT_P330 "768588" @default.
- NCIT_C120304 NCIT_P375 "CYP17/Androgen Receptor Inhibitor ODM 204" @default.
- NCIT_C120304 NCIT_P399 "768588" @default.
- NCIT_C120304 normalizedInformationContent "100" @default.
- NCIT_C120304 referenceCount "1" @default.
- NCIT_C120304 hasExactSynonym "CYP17/Androgen Receptor Inhibitor ODM 204" @default.
- NCIT_C120304 hasExactSynonym "ODM 204" @default.
- NCIT_C120304 hasExactSynonym "ODM-204" @default.
- NCIT_C120304 inSubset NCIT_C128784 @default.
- NCIT_C120304 inSubset NCIT_C157711 @default.
- NCIT_C120304 inSubset NCIT_C157712 @default.
- NCIT_C120304 inSubset NCIT_C176424 @default.
- NCIT_C120304 inSubset NCIT_C177537 @default.
- NCIT_C120304 type Class @default.
- NCIT_C120304 isDefinedBy ncit.owl @default.
- NCIT_C120304 label "CYP17/Androgen Receptor Inhibitor ODM 204" @default.
- NCIT_C120304 subClassOf NCIT_C120304 @default.
- NCIT_C120304 subClassOf NCIT_C147908 @default.
- NCIT_C120304 subClassOf NCIT_C147923 @default.
- NCIT_C120304 subClassOf NCIT_C1908 @default.
- NCIT_C120304 subClassOf NCIT_C1909 @default.
- NCIT_C120304 subClassOf NCIT_C242 @default.
- NCIT_C120304 subClassOf NCIT_C471 @default.
- NCIT_C120304 subClassOf NCIT_C547 @default.