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- NCIT_C120307 IAO_0000115 "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Mavelertinib specifically binds to and inhibits EGFR T790M, a secondary acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR/T790M-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06747775 may have therapeutic benefits in tumors with T790M-mediated drug resistance. This agent shows minimal activity against wild-type EGFR (WT EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which can inhibit WT EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C120307 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120307 NCIT_A7 NCIT_C98503 @default.
- NCIT_C120307 NCIT_NHC0 "C120307" @default.
- NCIT_C120307 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120307 NCIT_P107 "Mavelertinib" @default.
- NCIT_C120307 NCIT_P108 "Mavelertinib" @default.
- NCIT_C120307 NCIT_P207 "C3896785" @default.
- NCIT_C120307 NCIT_P210 "1776112-90-3" @default.
- NCIT_C120307 NCIT_P319 "YXX2180047" @default.
- NCIT_C120307 NCIT_P322 "CTRP" @default.
- NCIT_C120307 NCIT_P322 "FDA" @default.
- NCIT_C120307 NCIT_P322 "GDC" @default.
- NCIT_C120307 NCIT_P329 "768709" @default.
- NCIT_C120307 NCIT_P330 "768709" @default.
- NCIT_C120307 NCIT_P375 "Mavelertinib" @default.
- NCIT_C120307 NCIT_P399 "768709" @default.
- NCIT_C120307 normalizedInformationContent "100" @default.
- NCIT_C120307 referenceCount "1" @default.
- NCIT_C120307 hasExactSynonym "2-Propenamide, N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)-3-pyrrolidinyl)-" @default.
- NCIT_C120307 hasExactSynonym "MAVELERTINIB" @default.
- NCIT_C120307 hasExactSynonym "Mavelertinib" @default.
- NCIT_C120307 hasExactSynonym "PF-06747775" @default.
- NCIT_C120307 inSubset NCIT_C116977 @default.
- NCIT_C120307 inSubset NCIT_C116978 @default.
- NCIT_C120307 inSubset NCIT_C128784 @default.
- NCIT_C120307 inSubset NCIT_C157711 @default.
- NCIT_C120307 inSubset NCIT_C157712 @default.
- NCIT_C120307 inSubset NCIT_C176424 @default.
- NCIT_C120307 inSubset NCIT_C177537 @default.
- NCIT_C120307 inSubset NCIT_C63923 @default.
- NCIT_C120307 type Class @default.
- NCIT_C120307 isDefinedBy ncit.owl @default.
- NCIT_C120307 label "Mavelertinib" @default.
- NCIT_C120307 subClassOf NCIT_C120307 @default.
- NCIT_C120307 subClassOf NCIT_C129824 @default.
- NCIT_C120307 subClassOf NCIT_C129825 @default.
- NCIT_C120307 subClassOf NCIT_C1404 @default.
- NCIT_C120307 subClassOf NCIT_C163758 @default.
- NCIT_C120307 subClassOf NCIT_C163952 @default.
- NCIT_C120307 subClassOf NCIT_C1908 @default.
- NCIT_C120307 subClassOf NCIT_C1909 @default.
- NCIT_C120307 subClassOf NCIT_C1967 @default.
- NCIT_C120307 subClassOf NCIT_C2167 @default.
- NCIT_C120307 subClassOf NCIT_C2189 @default.
- NCIT_C120307 subClassOf NCIT_C274 @default.
- NCIT_C120307 subClassOf NCIT_C471 @default.