Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C120312> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- NCIT_C120312 IAO_0000115 "An orally bioavailable N-hydroxyacrylamide-derived inhibitor of both human pan-histone deacetylase (HDAC) enzymes and the serine/threonine protein kinase Akt (protein kinase B), with potential antineoplastic activity. Upon administration, HDAC inhibitor MPT0E028 selectively binds to and inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the accumulation of highly acetylated histones. This may result in both an induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. This prevents cell division and induces both cell cycle arrest and apoptosis, which may inhibit the proliferation of susceptible tumor cells. In addition, MPT0E028 inhibits the phosphorylation and activation of Akt, which prevents the activation of downstream signaling pathways, independent of its HDAC inhibitory activity. HDACs, upregulated in many tumor cell types, are a family of enzymes that deacetylate histone proteins. Akt, overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C120312 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120312 NCIT_A7 NCIT_C16682 @default.
- NCIT_C120312 NCIT_NHC0 "C120312" @default.
- NCIT_C120312 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120312 NCIT_P108 "HDAC Inhibitor MPT0E028" @default.
- NCIT_C120312 NCIT_P207 "C3661262" @default.
- NCIT_C120312 NCIT_P210 "1338320-94-7" @default.
- NCIT_C120312 NCIT_P322 "GDC" @default.
- NCIT_C120312 NCIT_P329 "768773" @default.
- NCIT_C120312 NCIT_P330 "768773" @default.
- NCIT_C120312 NCIT_P375 "HDAC Inhibitor MPT0E028" @default.
- NCIT_C120312 NCIT_P399 "768773" @default.
- NCIT_C120312 normalizedInformationContent "100" @default.
- NCIT_C120312 referenceCount "1" @default.
- NCIT_C120312 hasExactSynonym "(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide" @default.
- NCIT_C120312 hasExactSynonym "3-(1-Benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxy-acrylamide" @default.
- NCIT_C120312 hasExactSynonym "HDAC Inhibitor MPT0E028" @default.
- NCIT_C120312 hasExactSynonym "MPT 0E028" @default.
- NCIT_C120312 hasExactSynonym "MPT-0E028" @default.
- NCIT_C120312 hasExactSynonym "MPT0E028" @default.
- NCIT_C120312 inSubset NCIT_C128784 @default.
- NCIT_C120312 inSubset NCIT_C157711 @default.
- NCIT_C120312 inSubset NCIT_C157712 @default.
- NCIT_C120312 inSubset NCIT_C176424 @default.
- NCIT_C120312 inSubset NCIT_C177537 @default.
- NCIT_C120312 type Class @default.
- NCIT_C120312 isDefinedBy ncit.owl @default.
- NCIT_C120312 label "HDAC Inhibitor MPT0E028" @default.
- NCIT_C120312 subClassOf NCIT_C120312 @default.
- NCIT_C120312 subClassOf NCIT_C129824 @default.
- NCIT_C120312 subClassOf NCIT_C129825 @default.
- NCIT_C120312 subClassOf NCIT_C163758 @default.
- NCIT_C120312 subClassOf NCIT_C1908 @default.
- NCIT_C120312 subClassOf NCIT_C1909 @default.
- NCIT_C120312 subClassOf NCIT_C1946 @default.
- NCIT_C120312 subClassOf NCIT_C2189 @default.
- NCIT_C120312 subClassOf NCIT_C274 @default.
- NCIT_C120312 subClassOf NCIT_C471 @default.