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- NCIT_C120317 IAO_0000115 "A humanized, Fc engineered, de-fucosylated monoclonal immunoglobulin G1 (IgG1) antibody directed against the bone marrow stromal cell antigen 1 (BST1/CD157), with potential antineoplastic activity. Upon intravenous infusion, anti-CD157 monoclonal antibody MEN1112 specifically binds to and induces an antibody dependent cell cytotoxic (ADCC) response against CD157-expressing tumor cells. CD157, also known as ADP-ribosyl cyclase 2, is a glycosyl-phosphatidylinositol (GPI)-anchored transmembrane protein belonging to the ADP-ribosyl-cyclase family and is overexpressed on certain cancer cell types. Fc-optimization of MEN1112, which involves the removal of fucose residues from its Fc domain, allows for enhanced Fc-gamma receptor binding on effector cells, such as natural killer (NK) cells, and further enhances tumor cell lysis." @default.
- NCIT_C120317 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120317 NCIT_NHC0 "C120317" @default.
- NCIT_C120317 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C120317 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C120317 NCIT_P108 "Anti-CD157 Monoclonal Antibody MEN1112" @default.
- NCIT_C120317 NCIT_P207 "C3896815" @default.
- NCIT_C120317 NCIT_P322 "GDC" @default.
- NCIT_C120317 NCIT_P329 "768862" @default.
- NCIT_C120317 NCIT_P330 "768862" @default.
- NCIT_C120317 NCIT_P375 "Anti-CD157 Monoclonal Antibody MEN1112" @default.
- NCIT_C120317 NCIT_P399 "768862" @default.
- NCIT_C120317 NCIT_R124 NCIT_C17710 @default.
- NCIT_C120317 NCIT_R124 NCIT_C17828 @default.
- NCIT_C120317 NCIT_R124 NCIT_C18219 @default.
- NCIT_C120317 NCIT_R124 NCIT_C19986 @default.
- NCIT_C120317 NCIT_R124 NCIT_C40474 @default.
- NCIT_C120317 normalizedInformationContent "100" @default.
- NCIT_C120317 referenceCount "1" @default.
- NCIT_C120317 hasExactSynonym "Anti-CD157 Monoclonal Antibody MEN1112" @default.
- NCIT_C120317 hasExactSynonym "MEN1112" @default.
- NCIT_C120317 inSubset NCIT_C128784 @default.
- NCIT_C120317 inSubset NCIT_C157711 @default.
- NCIT_C120317 inSubset NCIT_C157712 @default.
- NCIT_C120317 inSubset NCIT_C176424 @default.
- NCIT_C120317 inSubset NCIT_C177537 @default.
- NCIT_C120317 type Class @default.
- NCIT_C120317 isDefinedBy ncit.owl @default.
- NCIT_C120317 label "Anti-CD157 Monoclonal Antibody MEN1112" @default.
- NCIT_C120317 subClassOf NCIT_C120317 @default.
- NCIT_C120317 subClassOf NCIT_C129821 @default.
- NCIT_C120317 subClassOf NCIT_C129822 @default.
- NCIT_C120317 subClassOf NCIT_C1908 @default.
- NCIT_C120317 subClassOf NCIT_C1909 @default.
- NCIT_C120317 subClassOf NCIT_C20401 @default.
- NCIT_C120317 subClassOf NCIT_C274 @default.
- NCIT_C120317 subClassOf NCIT_C307 @default.
- NCIT_C120317 subClassOf NCIT_C308 @default.