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- NCIT_C120474 IAO_0000115 "A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 2 by the CYP450 enzymes 1A1/1A2. Theoretically, 2-hydroxyestradiol (2-OHE2) is able to undergo redox cycling, which generates active radicals and induces DNA damage; however, this estradiol metabolite is very unstable in vivo and is quickly inactivated by catechol-O-methyltransferase (COMT)-mediated O-methylation and converted to 2-methoxyestradiol (2-MeE2). 2-MeE2 exerts antineoplastic activities through its estrogen receptor antagonistic effect and the induction of apoptosis in susceptible cancer cells." @default.
- NCIT_C120474 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120474 NCIT_NHC0 "C120474" @default.
- NCIT_C120474 NCIT_P106 "Organic Chemical" @default.
- NCIT_C120474 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120474 NCIT_P107 "2-Hydroxyestradiol" @default.
- NCIT_C120474 NCIT_P108 "2-Hydroxyestradiol" @default.
- NCIT_C120474 NCIT_P207 "C0046196" @default.
- NCIT_C120474 NCIT_P210 "362-05-0" @default.
- NCIT_C120474 NCIT_P319 "AYU2L67YUU" @default.
- NCIT_C120474 NCIT_P322 "CTRP" @default.
- NCIT_C120474 NCIT_P322 "FDA" @default.
- NCIT_C120474 NCIT_P322 "GDC" @default.
- NCIT_C120474 NCIT_P368 "CHEBI:28744" @default.
- NCIT_C120474 NCIT_P375 "2-Hydroxyestradiol" @default.
- NCIT_C120474 normalizedInformationContent "100" @default.
- NCIT_C120474 referenceCount "1" @default.
- NCIT_C120474 hasExactSynonym "(17beta)-Estra-1,3,5(10)-Triene-2,3,17-Triol" @default.
- NCIT_C120474 hasExactSynonym "2-HYDROXYESTRADIOL" @default.
- NCIT_C120474 hasExactSynonym "2-Hydroxy-17beta-Estradiol" @default.
- NCIT_C120474 hasExactSynonym "2-Hydroxyestradiol" @default.
- NCIT_C120474 hasExactSynonym "2-Hydroxyestradiol-17beta" @default.
- NCIT_C120474 hasExactSynonym "2-OH-E2" @default.
- NCIT_C120474 hasExactSynonym "2-OH-Estradiol" @default.
- NCIT_C120474 hasExactSynonym "2-OHE2" @default.
- NCIT_C120474 inSubset NCIT_C116977 @default.
- NCIT_C120474 inSubset NCIT_C128784 @default.
- NCIT_C120474 inSubset NCIT_C142799 @default.
- NCIT_C120474 inSubset NCIT_C157711 @default.
- NCIT_C120474 inSubset NCIT_C157712 @default.
- NCIT_C120474 inSubset NCIT_C177537 @default.
- NCIT_C120474 inSubset NCIT_C63923 @default.
- NCIT_C120474 type Class @default.
- NCIT_C120474 isDefinedBy ncit.owl @default.
- NCIT_C120474 label "2-Hydroxyestradiol" @default.
- NCIT_C120474 subClassOf NCIT_C120474 @default.
- NCIT_C120474 subClassOf NCIT_C147908 @default.
- NCIT_C120474 subClassOf NCIT_C1636 @default.
- NCIT_C120474 subClassOf NCIT_C1908 @default.
- NCIT_C120474 subClassOf NCIT_C1909 @default.
- NCIT_C120474 subClassOf NCIT_C2181 @default.
- NCIT_C120474 subClassOf NCIT_C483 @default.
- NCIT_C120474 subClassOf NCIT_C548 @default.