Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C120546> ?p ?o ?g. }
Showing items 1 to 41 of
41
with 100 items per page.
- NCIT_C120546 IAO_0000115 "An engineered toxin body (ETB) composed of the single-chain variable fragment (ScFv) from an antibody targeting CD20 that is linked to a modified form of the ribosome-inactivating alpha subunit of Shiga-like toxin 1 (Shiga-like Toxin-1 A or SLT-1A), with antineoplastic activity. Upon administration, the ScFv moiety of anti-CD20-engineered toxin body MT-3724 targets and binds to the CD20 antigen expressed on tumor cells. Upon internalization, the SLT-1A moiety is released and acts as an N-glycosidase, which binds to and cleaves an adenine nucleobase in the 28S RNA component of the 60S subunit of ribosomes and prevents ribosome activity. This inhibits protein synthesis and eventually leads to apoptosis of CD20-expressing tumor cells. CD20, a B-cell specific transmembrane protein and tumor-associated antigen (TAA), is expressed during most stages of B-cell development and is often overexpressed in B-cell malignancies." @default.
- NCIT_C120546 NCIT_A32 NCIT_C1909 @default.
- NCIT_C120546 NCIT_A7 NCIT_C38896 @default.
- NCIT_C120546 NCIT_NHC0 "C120546" @default.
- NCIT_C120546 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120546 NCIT_P107 "Anti-CD20-engineered Toxin Body MT-3724" @default.
- NCIT_C120546 NCIT_P108 "Anti-CD20-engineered Toxin Body MT-3724" @default.
- NCIT_C120546 NCIT_P207 "C4053580" @default.
- NCIT_C120546 NCIT_P319 "R23ZRN6GWR" @default.
- NCIT_C120546 NCIT_P322 "CTRP" @default.
- NCIT_C120546 NCIT_P322 "FDA" @default.
- NCIT_C120546 NCIT_P322 "GDC" @default.
- NCIT_C120546 NCIT_P329 "769207" @default.
- NCIT_C120546 NCIT_P330 "769207" @default.
- NCIT_C120546 NCIT_P375 "Anti-CD20-engineered Toxin Body MT-3724" @default.
- NCIT_C120546 NCIT_P399 "769207" @default.
- NCIT_C120546 normalizedInformationContent "100" @default.
- NCIT_C120546 referenceCount "1" @default.
- NCIT_C120546 hasExactSynonym "Anti-CD20-engineered Toxin Body MT-3724" @default.
- NCIT_C120546 hasExactSynonym "MT-3724" @default.
- NCIT_C120546 inSubset NCIT_C116977 @default.
- NCIT_C120546 inSubset NCIT_C116978 @default.
- NCIT_C120546 inSubset NCIT_C128784 @default.
- NCIT_C120546 inSubset NCIT_C157711 @default.
- NCIT_C120546 inSubset NCIT_C157712 @default.
- NCIT_C120546 inSubset NCIT_C176424 @default.
- NCIT_C120546 inSubset NCIT_C177537 @default.
- NCIT_C120546 inSubset NCIT_C63923 @default.
- NCIT_C120546 type Class @default.
- NCIT_C120546 isDefinedBy ncit.owl @default.
- NCIT_C120546 label "Anti-CD20-engineered Toxin Body MT-3724" @default.
- NCIT_C120546 subClassOf NCIT_C120546 @default.
- NCIT_C120546 subClassOf NCIT_C1512 @default.
- NCIT_C120546 subClassOf NCIT_C163758 @default.
- NCIT_C120546 subClassOf NCIT_C164034 @default.
- NCIT_C120546 subClassOf NCIT_C1908 @default.
- NCIT_C120546 subClassOf NCIT_C1909 @default.
- NCIT_C120546 subClassOf NCIT_C274 @default.
- NCIT_C120546 subClassOf NCIT_C307 @default.
- NCIT_C120546 subClassOf NCIT_C308 @default.
- NCIT_C120546 subClassOf NCIT_C575 @default.