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- NCIT_C120551 IAO_0000115 "A sustained-release (SR), oil-based oral capsule composed of a cannabis extract, which contains a variety of cannabinoids but is comprised mainly of tetrahydrocannabinol (THC), with potential anti-cachexic and analgesic activities. Upon oral administration, the cannabinoids bind to the cannabinoid G-protein coupled receptor CB1, which is located in both central and peripheral neurons; CB1 receptor activation inhibits adenyl cyclase, increases various signal transduction pathways, and modulates the activity of various ion channels. This provides an analgesic effect, increases appetite, decreases chemotherapy-induced nausea and vomiting, and improves weight gain. The formulation allows for the immediate release of cannabinoids and quick onset of action, which is followed by a gradual release of cannabinoids. The SR form facilitates longer lasting therapeutic effects and causes fewer psychoactive side effects when compared to non-SR cannabinoid-containing oral formulations." @default.
- NCIT_C120551 NCIT_NHC0 "C120551" @default.
- NCIT_C120551 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C120551 NCIT_P108 "Cannabis Extract Oil SR Capsule" @default.
- NCIT_C120551 NCIT_P207 "C4055277" @default.
- NCIT_C120551 NCIT_P329 "769170" @default.
- NCIT_C120551 NCIT_P330 "769170" @default.
- NCIT_C120551 NCIT_P399 "769170" @default.
- NCIT_C120551 normalizedInformationContent "100" @default.
- NCIT_C120551 referenceCount "1" @default.
- NCIT_C120551 hasExactSynonym "Cannabics SR" @default.
- NCIT_C120551 hasExactSynonym "Cannabis Extract Oil SR Capsule" @default.
- NCIT_C120551 hasExactSynonym "Cannabis SR Capsule" @default.
- NCIT_C120551 hasExactSynonym "Cannabis SR Capsules" @default.
- NCIT_C120551 inSubset NCIT_C176424 @default.
- NCIT_C120551 type Class @default.
- NCIT_C120551 isDefinedBy ncit.owl @default.
- NCIT_C120551 label "Cannabis Extract Oil SR Capsule" @default.
- NCIT_C120551 subClassOf NCIT_C120551 @default.
- NCIT_C120551 subClassOf NCIT_C1908 @default.
- NCIT_C120551 subClassOf NCIT_C1909 @default.
- NCIT_C120551 subClassOf NCIT_C1935 @default.
- NCIT_C120551 subClassOf NCIT_C78281 @default.