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- NCIT_C121158 IAO_0000115 "An agonistic monoclonal antibody directed against human death receptor type 5 (DR5), also called tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2, with potential pro-apoptotic and antitumor activities. Upon administration, anti-DR5 agonistic antibody DS-8273a mimics the natural receptor ligand TRAIL and binds to DR5. This activates DR5 and leads to the activation of the death receptor signal pathway, which results in the activation of caspase cascades, the induction of tumor cell apoptosis and a reduction in proliferation of DR5-expressing tumor cells. DR5, a member of the TNF receptor superfamily, is expressed on the surfaces of a variety of tumor cells and plays a key role in the induction of tumor cell apoptosis." @default.
- NCIT_C121158 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121158 NCIT_A7 NCIT_C18178 @default.
- NCIT_C121158 NCIT_NHC0 "C121158" @default.
- NCIT_C121158 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C121158 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121158 NCIT_P107 "Anti-DR5 Agonistic Antibody DS-8273a" @default.
- NCIT_C121158 NCIT_P108 "Anti-DR5 Agonistic Antibody DS-8273a" @default.
- NCIT_C121158 NCIT_P208 "CL471819" @default.
- NCIT_C121158 NCIT_P210 "2107396-50-7" @default.
- NCIT_C121158 NCIT_P319 "G674PEN33T" @default.
- NCIT_C121158 NCIT_P322 "CTRP" @default.
- NCIT_C121158 NCIT_P322 "FDA" @default.
- NCIT_C121158 NCIT_P322 "GDC" @default.
- NCIT_C121158 NCIT_P329 "758683" @default.
- NCIT_C121158 NCIT_P330 "758683" @default.
- NCIT_C121158 NCIT_P375 "Anti-DR5 Agonistic Antibody DS-8273a" @default.
- NCIT_C121158 NCIT_P399 "758683" @default.
- NCIT_C121158 NCIT_R124 NCIT_C17710 @default.
- NCIT_C121158 NCIT_R124 NCIT_C17828 @default.
- NCIT_C121158 NCIT_R124 NCIT_C18219 @default.
- NCIT_C121158 NCIT_R124 NCIT_C19986 @default.
- NCIT_C121158 NCIT_R124 NCIT_C40474 @default.
- NCIT_C121158 normalizedInformationContent "100" @default.
- NCIT_C121158 referenceCount "1" @default.
- NCIT_C121158 hasExactSynonym "Anti-DR5 Agonistic Antibody DS-8273a" @default.
- NCIT_C121158 hasExactSynonym "DS 8273" @default.
- NCIT_C121158 hasExactSynonym "DS-8273A" @default.
- NCIT_C121158 hasExactSynonym "DS-8273a" @default.
- NCIT_C121158 inSubset NCIT_C116977 @default.
- NCIT_C121158 inSubset NCIT_C116978 @default.
- NCIT_C121158 inSubset NCIT_C128784 @default.
- NCIT_C121158 inSubset NCIT_C157711 @default.
- NCIT_C121158 inSubset NCIT_C157712 @default.
- NCIT_C121158 inSubset NCIT_C176424 @default.
- NCIT_C121158 inSubset NCIT_C177537 @default.
- NCIT_C121158 inSubset NCIT_C63923 @default.
- NCIT_C121158 type Class @default.
- NCIT_C121158 isDefinedBy ncit.owl @default.
- NCIT_C121158 label "Anti-DR5 Agonistic Antibody DS-8273a" @default.
- NCIT_C121158 subClassOf NCIT_C121158 @default.
- NCIT_C121158 subClassOf NCIT_C171189 @default.
- NCIT_C121158 subClassOf NCIT_C1908 @default.
- NCIT_C121158 subClassOf NCIT_C1909 @default.
- NCIT_C121158 subClassOf NCIT_C20401 @default.
- NCIT_C121158 subClassOf NCIT_C307 @default.
- NCIT_C121158 subClassOf NCIT_C308 @default.
- NCIT_C121158 subClassOf NCIT_C574 @default.