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- NCIT_C121214 IAO_0000115 "A nanoparticle-based formulation composed of a microRNA 16 (miR-16) mimic, a double-stranded, 23 base pair, synthetic RNA molecule, encapsulated in nonliving bacterial minicells and coated with anti-epidermal growth factor receptor (EGFR) antibodies, with potential antineoplastic activity. Upon intravenous administration and subsequent transfection, nanocell-encapsulated miR-16-based microRNA mimic targets EGFR-expressing tumor cells and facilitates the restoration of expression of the miR-16 family. This leads to the downregulation of the expression of tumor promoting genes and the inhibition of tumor cell growth. In addition, restoration of miR-16 expression sensitizes the tumor cell to certain chemotherapeutic agents. miR-16, a family of microRNAs, is critical to the regulation of gene expression and appears to have a tumor suppressor function; its expression is downregulated in various cancer cell types." @default.
- NCIT_C121214 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121214 NCIT_NHC0 "C121214" @default.
- NCIT_C121214 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121214 NCIT_P108 "Nanocell-encapsulated miR-16-based microRNA Mimic" @default.
- NCIT_C121214 NCIT_P207 "C4054425" @default.
- NCIT_C121214 NCIT_P322 "GDC" @default.
- NCIT_C121214 NCIT_P329 "769608" @default.
- NCIT_C121214 NCIT_P330 "769608" @default.
- NCIT_C121214 NCIT_P375 "Nanocell-encapsulated miR-16-based microRNA Mimic" @default.
- NCIT_C121214 NCIT_P399 "769608" @default.
- NCIT_C121214 normalizedInformationContent "100" @default.
- NCIT_C121214 referenceCount "1" @default.
- NCIT_C121214 hasExactSynonym "Nanocell-encapsulated miR-16-based microRNA Mimic" @default.
- NCIT_C121214 hasExactSynonym "TargomiRs" @default.
- NCIT_C121214 inSubset NCIT_C128784 @default.
- NCIT_C121214 inSubset NCIT_C157711 @default.
- NCIT_C121214 inSubset NCIT_C157712 @default.
- NCIT_C121214 inSubset NCIT_C176424 @default.
- NCIT_C121214 inSubset NCIT_C177537 @default.
- NCIT_C121214 type Class @default.
- NCIT_C121214 isDefinedBy ncit.owl @default.
- NCIT_C121214 label "Nanocell-encapsulated miR-16-based microRNA Mimic" @default.
- NCIT_C121214 subClassOf NCIT_C121214 @default.
- NCIT_C121214 subClassOf NCIT_C163758 @default.
- NCIT_C121214 subClassOf NCIT_C163952 @default.
- NCIT_C121214 subClassOf NCIT_C1908 @default.
- NCIT_C121214 subClassOf NCIT_C1909 @default.
- NCIT_C121214 subClassOf NCIT_C2189 @default.
- NCIT_C121214 subClassOf NCIT_C274 @default.