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- NCIT_C121215 IAO_0000115 "An inhibitor of the 19S proteasome-specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis-inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly-ubiquitylated proteins. This induces the unfolded protein response (UPR) and results in both the induction of tumor cell apoptosis and the inhibition of tumor cell growth. USP14 and UCHL5, overexpressed in various tumor cell types, play a key role in the correct folding and deubiquitination of proteins." @default.
- NCIT_C121215 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121215 NCIT_A7 NCIT_C132092 @default.
- NCIT_C121215 NCIT_A7 NCIT_C158570 @default.
- NCIT_C121215 NCIT_NHC0 "C121215" @default.
- NCIT_C121215 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121215 NCIT_P107 "USP14/UCHL5 Inhibitor VLX1570" @default.
- NCIT_C121215 NCIT_P108 "USP14/UCHL5 Inhibitor VLX1570" @default.
- NCIT_C121215 NCIT_P207 "C4053575" @default.
- NCIT_C121215 NCIT_P210 "1956378-23-6" @default.
- NCIT_C121215 NCIT_P319 "K6067N5M6N" @default.
- NCIT_C121215 NCIT_P322 "CTRP" @default.
- NCIT_C121215 NCIT_P322 "FDA" @default.
- NCIT_C121215 NCIT_P322 "GDC" @default.
- NCIT_C121215 NCIT_P329 "769736" @default.
- NCIT_C121215 NCIT_P330 "769736" @default.
- NCIT_C121215 NCIT_P375 "USP14/UCHL5 Inhibitor VLX1570" @default.
- NCIT_C121215 NCIT_P399 "769736" @default.
- NCIT_C121215 normalizedInformationContent "100" @default.
- NCIT_C121215 referenceCount "1" @default.
- NCIT_C121215 hasExactSynonym "USP14/UCHL5 Inhibitor VLX1570" @default.
- NCIT_C121215 hasExactSynonym "VLX-1570" @default.
- NCIT_C121215 hasExactSynonym "VLX1570" @default.
- NCIT_C121215 inSubset NCIT_C116977 @default.
- NCIT_C121215 inSubset NCIT_C116978 @default.
- NCIT_C121215 inSubset NCIT_C128784 @default.
- NCIT_C121215 inSubset NCIT_C157711 @default.
- NCIT_C121215 inSubset NCIT_C157712 @default.
- NCIT_C121215 inSubset NCIT_C176424 @default.
- NCIT_C121215 inSubset NCIT_C177537 @default.
- NCIT_C121215 inSubset NCIT_C63923 @default.
- NCIT_C121215 type Class @default.
- NCIT_C121215 isDefinedBy ncit.owl @default.
- NCIT_C121215 label "USP14/UCHL5 Inhibitor VLX1570" @default.
- NCIT_C121215 subClassOf NCIT_C121215 @default.
- NCIT_C121215 subClassOf NCIT_C163758 @default.
- NCIT_C121215 subClassOf NCIT_C1908 @default.
- NCIT_C121215 subClassOf NCIT_C1909 @default.
- NCIT_C121215 subClassOf NCIT_C2160 @default.
- NCIT_C121215 subClassOf NCIT_C274 @default.
- NCIT_C121215 subClassOf NCIT_C471 @default.