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- NCIT_C121217 IAO_0000115 "A proprietary, non-fucosylated monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, cifurtilimab binds to CD40 on a variety of immune cell types, triggering both cellular proliferation and activation of antigen-presenting cells (APCs), which activates B-cells and T-cells, and enhances the immune response against tumor cells. In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC), and eventually inhibits the proliferation of CD40-expressing tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells, such as macrophages, dendritic cells and various tumor cell types; it plays a key role in the activation of the immune system. The non-fucosylated antibody shows increased efficacy as compared to its fucosylated counterpart." @default.
- NCIT_C121217 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121217 NCIT_A7 NCIT_C17281 @default.
- NCIT_C121217 NCIT_NHC0 "C121217" @default.
- NCIT_C121217 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C121217 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121217 NCIT_P107 "Cifurtilimab" @default.
- NCIT_C121217 NCIT_P108 "Cifurtilimab" @default.
- NCIT_C121217 NCIT_P207 "C4053590" @default.
- NCIT_C121217 NCIT_P319 "BY4DOG9SMH" @default.
- NCIT_C121217 NCIT_P322 "CTRP" @default.
- NCIT_C121217 NCIT_P322 "FDA" @default.
- NCIT_C121217 NCIT_P322 "GDC" @default.
- NCIT_C121217 NCIT_P329 "769820" @default.
- NCIT_C121217 NCIT_P330 "769820" @default.
- NCIT_C121217 NCIT_P375 "Anti-CD40 Monoclonal Antibody SEA-CD40" @default.
- NCIT_C121217 NCIT_P399 "769820" @default.
- NCIT_C121217 NCIT_R124 NCIT_C17710 @default.
- NCIT_C121217 NCIT_R124 NCIT_C17828 @default.
- NCIT_C121217 NCIT_R124 NCIT_C18219 @default.
- NCIT_C121217 NCIT_R124 NCIT_C19986 @default.
- NCIT_C121217 NCIT_R124 NCIT_C40474 @default.
- NCIT_C121217 normalizedInformationContent "100" @default.
- NCIT_C121217 referenceCount "1" @default.
- NCIT_C121217 hasExactSynonym "Anti-CD40 Monoclonal Antibody SEA-CD40" @default.
- NCIT_C121217 hasExactSynonym "CIFURTILIMAB" @default.
- NCIT_C121217 hasExactSynonym "Cifurtilimab" @default.
- NCIT_C121217 hasExactSynonym "SEA CD40" @default.
- NCIT_C121217 hasExactSynonym "SEA-CD40" @default.
- NCIT_C121217 inSubset NCIT_C116977 @default.
- NCIT_C121217 inSubset NCIT_C116978 @default.
- NCIT_C121217 inSubset NCIT_C128784 @default.
- NCIT_C121217 inSubset NCIT_C157711 @default.
- NCIT_C121217 inSubset NCIT_C157712 @default.
- NCIT_C121217 inSubset NCIT_C176424 @default.
- NCIT_C121217 inSubset NCIT_C177537 @default.
- NCIT_C121217 inSubset NCIT_C63923 @default.
- NCIT_C121217 type Class @default.
- NCIT_C121217 isDefinedBy ncit.owl @default.
- NCIT_C121217 label "Cifurtilimab" @default.
- NCIT_C121217 subClassOf NCIT_C121217 @default.
- NCIT_C121217 subClassOf NCIT_C129820 @default.
- NCIT_C121217 subClassOf NCIT_C133877 @default.
- NCIT_C121217 subClassOf NCIT_C1908 @default.
- NCIT_C121217 subClassOf NCIT_C1909 @default.
- NCIT_C121217 subClassOf NCIT_C191767 @default.
- NCIT_C121217 subClassOf NCIT_C20401 @default.
- NCIT_C121217 subClassOf NCIT_C274 @default.
- NCIT_C121217 subClassOf NCIT_C307 @default.
- NCIT_C121217 subClassOf NCIT_C308 @default.