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- NCIT_C121231 IAO_0000115 "A humanized version of the immunoglobulin (Ig) G1 monoclonal antibody Mik-Beta-1 (Hu-Mik-Beta-1) directed against CD122, the beta-subunit shared by the interleukin-2 (IL-2) and IL-15 receptor (IL-2/IL-15Rbeta). Upon intravenous infusion, Hu-Mik-Beta-1 binds to CD122 expressed on certain tumor cells. This blocks the binding of the inflammatory cytokines IL-2 and IL-15 to IL-2R and IL-15R, respectively, and prevents IL-2/IL-2R- and IL-15/IL-15R-mediated signaling. This may inhibit the proliferation of CD122-expressing tumor cells. In addition, blocking CD122 on T-lymphocytes prevents the over-activation of T-lymphocytes in various T-cell mediated autoimmune diseases, which is predominantly mediated by IL-15/IL-15R signaling. CD122, involved in both IL-2 and IL-15 signaling, is overexpressed on certain cancer cells, such as those found in T-cell large granular lymphocyte (T-LGL) leukemia." @default.
- NCIT_C121231 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121231 NCIT_A7 NCIT_C26267 @default.
- NCIT_C121231 NCIT_NHC0 "C121231" @default.
- NCIT_C121231 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121231 NCIT_P107 "Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1" @default.
- NCIT_C121231 NCIT_P108 "Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1" @default.
- NCIT_C121231 NCIT_P207 "C4055462" @default.
- NCIT_C121231 NCIT_P322 "CTRP" @default.
- NCIT_C121231 NCIT_P322 "GDC" @default.
- NCIT_C121231 NCIT_P375 "Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1" @default.
- NCIT_C121231 NCIT_P399 "810708" @default.
- NCIT_C121231 NCIT_R124 NCIT_C17710 @default.
- NCIT_C121231 NCIT_R124 NCIT_C17828 @default.
- NCIT_C121231 NCIT_R124 NCIT_C18219 @default.
- NCIT_C121231 NCIT_R124 NCIT_C19986 @default.
- NCIT_C121231 NCIT_R124 NCIT_C40474 @default.
- NCIT_C121231 normalizedInformationContent "100" @default.
- NCIT_C121231 referenceCount "1" @default.
- NCIT_C121231 hasExactSynonym "Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1" @default.
- NCIT_C121231 hasExactSynonym "Hu-Mik-Beta-1" @default.
- NCIT_C121231 hasExactSynonym "Hu-Mik-beta1" @default.
- NCIT_C121231 hasExactSynonym "Hu-Mikb1" @default.
- NCIT_C121231 hasExactSynonym "HuMikBeta1" @default.
- NCIT_C121231 hasExactSynonym "Humanized Mik-beta-1" @default.
- NCIT_C121231 inSubset NCIT_C116977 @default.
- NCIT_C121231 inSubset NCIT_C116978 @default.
- NCIT_C121231 inSubset NCIT_C128784 @default.
- NCIT_C121231 inSubset NCIT_C157711 @default.
- NCIT_C121231 inSubset NCIT_C157712 @default.
- NCIT_C121231 inSubset NCIT_C176424 @default.
- NCIT_C121231 inSubset NCIT_C177537 @default.
- NCIT_C121231 type Class @default.
- NCIT_C121231 isDefinedBy ncit.owl @default.
- NCIT_C121231 label "Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1" @default.
- NCIT_C121231 subClassOf NCIT_C121231 @default.
- NCIT_C121231 subClassOf NCIT_C129821 @default.
- NCIT_C121231 subClassOf NCIT_C129822 @default.
- NCIT_C121231 subClassOf NCIT_C141144 @default.
- NCIT_C121231 subClassOf NCIT_C1908 @default.
- NCIT_C121231 subClassOf NCIT_C1909 @default.
- NCIT_C121231 subClassOf NCIT_C20401 @default.
- NCIT_C121231 subClassOf NCIT_C274 @default.
- NCIT_C121231 subClassOf NCIT_C307 @default.
- NCIT_C121231 subClassOf NCIT_C308 @default.