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- NCIT_C1214 IAO_0000115 "A naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons." @default.
- NCIT_C1214 NCIT_NHC0 "C1214" @default.
- NCIT_C1214 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1214 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1214 NCIT_P108 "Resiniferatoxin" @default.
- NCIT_C1214 NCIT_P207 "C0073081" @default.
- NCIT_C1214 NCIT_P210 "57444-62-9" @default.
- NCIT_C1214 NCIT_P319 "A5O6P1UL4I" @default.
- NCIT_C1214 NCIT_P322 "FDA" @default.
- NCIT_C1214 NCIT_P329 "630743" @default.
- NCIT_C1214 NCIT_P330 "630743" @default.
- NCIT_C1214 NCIT_P366 "Resiniferatoxin" @default.
- NCIT_C1214 NCIT_P399 "630743" @default.
- NCIT_C1214 normalizedInformationContent "100" @default.
- NCIT_C1214 referenceCount "1" @default.
- NCIT_C1214 hasExactSynonym "RESINIFERATOXIN" @default.
- NCIT_C1214 hasExactSynonym "RTX" @default.
- NCIT_C1214 hasExactSynonym "Resiniferatoxin" @default.
- NCIT_C1214 inSubset NCIT_C176424 @default.
- NCIT_C1214 inSubset NCIT_C63923 @default.
- NCIT_C1214 type Class @default.
- NCIT_C1214 isDefinedBy ncit.owl @default.
- NCIT_C1214 label "Resiniferatoxin" @default.
- NCIT_C1214 subClassOf NCIT_C1214 @default.
- NCIT_C1214 subClassOf NCIT_C1908 @default.
- NCIT_C1214 subClassOf NCIT_C1909 @default.
- NCIT_C1214 subClassOf NCIT_C2198 @default.
- NCIT_C1214 subClassOf NCIT_C241 @default.
- NCIT_C1214 subClassOf NCIT_C78272 @default.