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- NCIT_C121456 IAO_0000115 "An inhibitor of positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin-T (CycT), with potential antineoplastic activity. Upon administration, atuveciclib binds to and inhibits the activity of P-TEFb, thereby preventing the phosphorylation of its downstream target, the carboxyl terminal domain (CTD) of RNA polymerase II (RNA Pol II), and inhibiting the activation of transcriptional elongation by RNA Pol II. This prevents the transcription of tumor promoting genes, induces tumor cell apoptosis, and inhibits tumor cell proliferation. P-TEFb plays an important role in the regulation of gene transcription; over-activation in cancer cells leads to both the transcription of key tumor-promoting genes and cancer cell proliferation." @default.
- NCIT_C121456 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121456 NCIT_NHC0 "C121456" @default.
- NCIT_C121456 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121456 NCIT_P107 "Atuveciclib" @default.
- NCIT_C121456 NCIT_P108 "Atuveciclib" @default.
- NCIT_C121456 NCIT_P208 "CL471744" @default.
- NCIT_C121456 NCIT_P210 "1414943-94-4" @default.
- NCIT_C121456 NCIT_P319 "63Q7F59W0V" @default.
- NCIT_C121456 NCIT_P322 "CTRP" @default.
- NCIT_C121456 NCIT_P322 "FDA" @default.
- NCIT_C121456 NCIT_P322 "GDC" @default.
- NCIT_C121456 NCIT_P329 "753347" @default.
- NCIT_C121456 NCIT_P330 "753347" @default.
- NCIT_C121456 NCIT_P375 "Atuveciclib" @default.
- NCIT_C121456 NCIT_P375 "P-TEFb Inhibitor BAY1143572" @default.
- NCIT_C121456 NCIT_P399 "753347" @default.
- NCIT_C121456 normalizedInformationContent "100" @default.
- NCIT_C121456 referenceCount "1" @default.
- NCIT_C121456 hasExactSynonym "1,3,5-Triazin-2-amine, 4-(4-Fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-, (+)-" @default.
- NCIT_C121456 hasExactSynonym "ATUVECICLIB" @default.
- NCIT_C121456 hasExactSynonym "Atuveciclib" @default.
- NCIT_C121456 hasExactSynonym "BAY 1143572" @default.
- NCIT_C121456 hasExactSynonym "BAY1143572" @default.
- NCIT_C121456 inSubset NCIT_C116977 @default.
- NCIT_C121456 inSubset NCIT_C116978 @default.
- NCIT_C121456 inSubset NCIT_C128784 @default.
- NCIT_C121456 inSubset NCIT_C157711 @default.
- NCIT_C121456 inSubset NCIT_C157712 @default.
- NCIT_C121456 inSubset NCIT_C176424 @default.
- NCIT_C121456 inSubset NCIT_C177537 @default.
- NCIT_C121456 inSubset NCIT_C63923 @default.
- NCIT_C121456 type Class @default.
- NCIT_C121456 isDefinedBy ncit.owl @default.
- NCIT_C121456 label "Atuveciclib" @default.
- NCIT_C121456 subClassOf NCIT_C121456 @default.
- NCIT_C121456 subClassOf NCIT_C129824 @default.
- NCIT_C121456 subClassOf NCIT_C129825 @default.
- NCIT_C121456 subClassOf NCIT_C1404 @default.
- NCIT_C121456 subClassOf NCIT_C163758 @default.
- NCIT_C121456 subClassOf NCIT_C1908 @default.
- NCIT_C121456 subClassOf NCIT_C1909 @default.
- NCIT_C121456 subClassOf NCIT_C200258 @default.
- NCIT_C121456 subClassOf NCIT_C2185 @default.
- NCIT_C121456 subClassOf NCIT_C2189 @default.
- NCIT_C121456 subClassOf NCIT_C274 @default.
- NCIT_C121456 subClassOf NCIT_C471 @default.
- NCIT_C121456 subClassOf NCIT_C61074 @default.